Xyzal/Levocetirizine Tablets

Levocetirizine is used to reduce the symptoms of a runny nose, sneezing and redness, itching, and watery eyes caused by hay fever from allergies and seasonal allergies to allergens like dust mites, animal dander, and molds. It can also be used to treat symptoms of hives, itching, and included skin rashes. Levocetirizine is usually given by mouth as a tablet to take once a day in the afternoon.

Functioning as an allergy treatment, Levocetirizine (R-cetirizine) is the active enantiomer of cetirizine, a second-generation antagonist of H1 receptors, it is the first antihistamine that is not a metabolite.

In vitro pharmacodynamic studies show that most of the antihistamine action of cetirizine is due to levocetirizine, so both compounds produce the same effect, using different doses. It is rapidly absorbed orally. The establishment of the answer appears after 1 hour, remaining for 24 h. Its hepatic metabolism is minimal, so most of the dose is excreted unchanged in the urine. Its plasma elimination half-life is 7 hours after administration of a single dose.

Levocetirizine dihydrochloride is the active substance in Levocetirizine 5 mg film-coated tablets EFG. Levocetirizine is an antiallergic medicine. Being one the known best allergy tablets, Levocetirizine Xyzal is used to treat signs of illness (symptoms) associated with:

• allergic rhinitis (including persistent allergic rhinitis)
• urticaria

Antihistamines such as levocetirizine alleviate the discomfort associated with the conditions described above, such as sneezing, irritation, runny nose and congestion, itching, redness of the eyes with tearing, and skin rash.

Always use this medicine exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again. The recommended levocetirizine xyzal dosage is as follows:

Adults and children 6 years and older

The recommended dose for adults and children from 6 years is one tablet per day.

Special instructions for dosing in specific populations:

Kidney and liver failure

Levocetirizine should not be taken by patients who have severe renal impairment (severe renal impairment with creatinine clearance less than 10 ml/min).

Patients with liver and kidney failure should take a lower dose depending on the severity of their kidney disease, and in children, the dose will be based on body weight; the dose to take will be determined by your doctor.

Patients with liver failure only should take the normal prescription dose.

Patients from 65 years of age

In elderly patients, no dosage adjustment is necessary if their renal function is normal.

Use in children

Levocetirizine is not recommended for use in children under 6 years of age.

The tablets are to be swallowed whole with water and can be taken with or without food. In addition, the duration of the treatment depends on the type, duration, and course of the symptoms and it is your doctor who must determine it.

Like all medicines, this medicine can have side effects, although not everybody gets them.

At the first signs of a hypersensitivity reaction, stop taking Levocetirizine and see your doctor immediately. Symptoms of the hypersensitivity reaction may include: swelling of the mouth, tongue, face and/or neck, difficulty breathing, or swallowing together with hives (angioedema), a sudden drop in blood pressure that can lead to collapse or shock, which can be fatal.

Common side effects (may affect up to 1 in 10 patients):

• dry mouth
• headache
• fatigue
• drowsiness.

Uncommon side effects (may affect up to 1 in 100 patients):

• exhaustion
• pain in the abdomen.

Frequency not known (cannot be estimated from the available data):

• increased appetite
• aggressive or agitated behavior, hallucinations, depression, insomnia, recurring thoughts, or concern with suicide
• seizures, tingling, dizziness, syncope, tremor, dysgeusia (altered sense of taste)
• A feeling of rotation or movement
• visual disturbances, blurred vision, oculogyric crisis (uncontrolled circular movements of the eyes)
• palpitations, increased heart rate
• shortness of breath
• Vomiting, diarrhea
• hepatitis, abnormal liver function
• pain or difficulty urinating, inability to completely empty the bladder
• medication skin rash, itching (itching), rash, hives (swelling, redness, and itching of the skin)
• itching (severe itching) when treatment is stopped
• muscle pain, joint pain
• edema
• Increased weight

Warnings and Precautions.

If you have any conditioning factors that make you unable to empty your urinary bladder (such as a damaged spinal cord or an enlarged prostate), please inform your doctor.

If you are epileptic or at risk of seizures, please consult your doctor.

If you are going to have an allergic test, ask your doctor if you need to stop taking Levocetirizine several days before. This medicine may affect the results of the allergic test.

Children

The use of Levocetirizine is not recommended in children under 6 years of age as the film-coated tablets do not allow a dose adjustment.

Levocetirizine with food, drink, and alcohol

Caution is advised if Levocetirizine is taken together with alcohol or other agents in the brain. Insensitive patients, the simultaneous taking of Levocetirizine with alcohol or other agents acting on the brain can cause a further decrease in attention span and decrease performance.

Pregnancy and lactation

If you are pregnant or breast-feeding, think you might be pregnant or intend to become pregnant, consult your doctor or pharmacist before using this medicine.

Driving and using machinery

Some patients treated with Levocetirizine may experience drowsiness/numbness, tiredness, and exhaustion. Be careful if you are going to drive or use machinery until you know how this medication may affect you. However, in special tests carried out on healthy people, no alterations in attention, reaction capacity, and driving ability were detected after taking levocetirizine at the recommended dose.

Levocetirizine contains lactose

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.

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