Trisequens

Trisequens is a sequentially combined hormone replacement therapy (HRT) that is taken every day without interruption. Trisequens is used in postmenopausal women whose last natural period occurred at least 6 months before use.

Trisequens contains 2 hormones, an estrogen (estradiol) and a progestogen (norethisterone acetate). The estradiol in Trisequens is identical to the estradiol produced by a woman's ovaries and is classified as natural estrogen. Norethisterone Acetate is a synthetic progestogen that acts similarly to progesterone, another important female sex hormone.

The active substance, synthetic 17-estradiol, is chemically and biologically identical to human endogenous estradiol. It substitutes the loss of estrogen production in menopausal women and relieves menopausal symptoms. Estrogens prevent bone loss after menopause or ovariectomy.

Norethisterone Acetate

Synthetic progestogen with actions similar to those of progesterone, a natural female sex hormone. Because estrogens promote endometrial growth, estrogens without increasing the risk of hyperplasia and endometrial cancer.

Trisequens uses include being indicated to:

Relieve symptoms that occur after menopause

During menopause, the amount of estrogen produced by a woman's body drops. This can produce symptoms such as heat on the face, neck, and chest ("hot flashes"). Trisequens relieves these symptoms after menopause. You will only be prescribed Trisequens if symptoms seriously hamper your daily life.

Prevent osteoporosis

After menopause, some women may have brittle bones (osteoporosis). You should discuss with your doctor what options are available.

If your risk of fractures due to osteoporosis increases, and there are no other medications that are right for you, you can use Trisequens to prevent osteoporosis after menopause.

The experience in treating elderly women (over 65 years) is limited.

Always use this medicine exactly as your doctor has told you. If in doubt, ask your doctor or pharmacist.

If you are not switching from another HRT product, you can start treatment with Trisequens any day that suits you. If you are switching from another hormone replacement therapy product, ask your doctor when you should start treatment with Trisequens.

Take one tablet once a day, at about the same time each day.

Each pack contains 28 tablets

• Days 1 to 12 Take one blue tablet each day for 12 days
• Days 13-22 Take one white tablet every day for 10 days
• Days 23-28 Take one red tablet every day for 6 days.

Take the tablet with a glass of water.

When you have finished the container, start a new container to continue the treatment without interruption. You will usually have to bleed similar to menstruation (period) when starting a new container.

Your doctor will attempt to prescribe the lowest effective dose and for the shortest possible time to provide relief from symptoms. Talk to your doctor if you think the dose is excessive or insufficient.

Talk to your doctor if you do not experience relief of symptoms after 3 months of treatment. Treatment should only be continued as long as the benefits outweigh the risks.

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The following disorders have been reported more frequently in women who use HRT than in those who do not:

• breast cancer
• abnormal growth or cancer of the lining of the uterus (endometrial hyperplasia or endometrial cancer)
• ovarian cancer
• blood clots in the veins of the legs or lungs (venous thromboembolism)
• heart disease
• stroke
• probable memory loss if HRT is started with more than 65 years of age.

Hypersensitivity / allergy (rare side effect - affects 1 to 10 users in 1,000)

• Although it is a rare effect, hypersensitivity/allergy may occur. Signs of hypersensitivity/allergy may include one or more of the following symptoms: hives, itching, swelling, shortness of breath, decreased blood pressure (pallor and cooling of the skin, increased heart rate), feeling dizzy and sweating They may be signs of an anaphylactic reaction or shock. If one of the above symptoms occurs, stop taking Trisequens and immediately seek medical help.

Very common Trisequens side effects

• Breast pain or tenderness
• Irregular periods or excessive bleeding during periods.

Frequent side effects

• Headache
• Weight gain due to fluid retention
• Vaginal inflammation
• Vaginal yeast infection
• Migraine, of new appearance or worsening of the existing one
• Depression, new-onset or worsening of existing
• nausea
• Abdominal pain, swelling, or discomfort
• Increase in size or swelling of the breasts (breast edema)
• Back pain
• Leg cramps
• Worsening, appearance or reappearance of uterine fibroid (benign tumor)
• Swelling of arms and legs (peripheral edema)
• Weight gain

Uncommon side effects

• Flatulence or meteorism
• Acne
• Hair loss (alopecia)
• Abnormal growth (male pattern) of hair
• Itching or hives (urticaria)
• Inflammation of a vein (superficial thrombophlebitis)
• Pharmacological ineffectiveness
• Allergic reaction
• Endometrial hyperplasia (excessive thickening of the lining of the uterus)
• Painful periods
• Nervousness

 Rare side effects

• Pulmonary embolism (blood clot)
• Deep inflammation of a vein associated with thrombosis (blood clot).

Very rare side effects

• Cancer of the lining of the uterus (endometrial cancer)
• Increased blood pressure or worsening of existing hypertension
• Gallbladder disease, gallstones that may be new, recurrence or worsening of existing ones
• Excessive sebum secretion, skin rash
• Acute or recurrent edema (angioneurotic edema)
• Insomnia, dizziness, anxiety
• Changes in sexual desire
• Vision disturbances
• Weightloss
• vomiting
• Gastric acidity
• Vaginal and genital itching
• Myocardial infarction and cerebrovascular accident.

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