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Trimovate Cream | Clobetasone, Nystatin & Oxytetracycline for Infected Eczema

Trimovate is anti-inflammatory skin cream. The medicine consists of three active ingredients:

  • Chlobetasone, an adrenal hormone that suppresses redness and swelling;
  • Oxytetracycline, an antibiotic that kills bacteria;
  • Nystatin, a fungicide.

It is a topical steroid indicated to reduce the redness and itching of certain skin problems. (Not to be confused with "anabolic" steroids misused by some bodybuilders and administered in the form of tablets or injections).  Apply the cream to a clean, dry area on the skin. Wash your hands immediately after application. If symptoms have not improved after seven days, you should see a doctor. Apply the medication to your face only if your doctor has told you to, and then only for as short a time as possible. The facial skin is relatively thin, making it extremely sensitive to side effects. Make sure that the cream does not come into contact with the eyes or mucous membranes.

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Trimovate Cream | Clobetasone, Nystatin & Oxytetracycline for Infected Eczema
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Starts at £34.00
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Trimovate Cream is a multi-purpose, prescription-only cream that contains three active ingredients: Clobetasone butyrate (a moderate-strength corticosteroid to help with inflammation), oxytetracycline hydrochloride (an antibiotic for bacterial-based infections), and nystatin (an antifungal agent to treat yeast or candida infections). Trimovate is typically prescribed for inflammatory skin conditions that are also affected by bacterial or fungal infections, particularly in areas where the skin folds, creating a moist and humid environment for bacteria and fungi to grow. Some of the conditions Trimovate can treat include infected eczema, intertrigo, candidal infections with inflammation, and other bacterial skin infections that cause redness and irritation. It offers anti-inflammatory, antibacterial, and antifungal properties in one application, eliminating the need for multiple treatments.

What is Trimovate Cream?

Trimovate cream comes in a tube with 15 grams or 30 grams of cream. This antifungal medication belongs to the group of medicines called topical steroids. "Topical" means it is applied to the skin. Topical steroids reduce the redness and itching of certain skin problems. (Not to be confused with "anabolic" steroids misused by some bodybuilders and administered in the form of tablets or injections). Always on prescription Trimovate cream is indicated for the treatment of eczema and dermatitis of all types.

How does it work?

The active ingredient in this Ezcema and psoriasis medication, Chlobetasone butyrate, is a corticosteroid whose anti-inflammatory action is moderately strong; thus, it is classified in Group 3 of the European Community list of corticosteroids for cutaneous use. It has a very wide margin of safety. Under conditions that predispose to maximum percutaneous absorption, Chlobetasone butyrate has a minimal effect on the hypothalamic-pituitary-adrenal cortical axis.

Clinical pharmacology studies carried out in animals and man have revealed the particularly high therapeutic index of this drug; In addition to good anti-inflammatory activity, a very low incidence of local and systemic side effects is observed, compared to other corticosteroids.

What are the benefits of taking it?

Trimovate cream is used to treat inflamed skin. Inflammation of the skin is often caused by bacteria or fungi, or a combination of these. Trimovate kills different types of bacteria and fungi, effectively treating the cause of the problem. Trimovate cream ensures that the skin is less red and swollen and also reduces symptoms such as pain and itching. This medication is increasingly prescribed for skin rashes, certain forms of acne, and infected eczema.

How do I use it and its dosage?

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Follow these instructions unless your doctor has given you different directions. Remember to take your medicine. Your doctor will indicate the duration of your treatment with Trimovate cream.  The usual dose is an application of a small amount of Trimovate cream on the affected area up to four times a day until there are an improvement and the application frequency. After washing your hands, apply the correct amount of cream to the affected areas of the skin until its disappearance. Unless used for treating hands, wash them again after applying the cream. Anyone who helps apply the cream should do the same or use disposable plastic gloves.

If in doubt, consult a doctor or pharmacist.

Using when pregnant

The application of topical steroids in pregnant animals can cause abnormalities in fetal development.

The relevance of these findings in humans has not been proven, however, topical steroids should not be used in pregnancy. Eg in large quantities or for long periods.

Side effects & precautions

Like all medicines, Trimovate side effects can occur. At the application site, local allergic reactions such as redness, itching, rash, hives, local burning of the skin, and allergic contact dermatitis, which may resemble symptoms of the skin condition being treated.

When large areas of the body are treated with Trimoovate cream, there may be a deletion transient adrenal. Local atrophic changes, changes in color, amount of hair, and exacerbation of the symptoms. If any other adverse reaction not described above is observed, consult your doctor or pharmacist.

Warnings and precautions

Long-term continued topical corticosteroid therapy in children and infants should be avoided whenever possible, as adrenal suppression may occur even without occlusion. In infants, the diaper can act as an occlusive dressing and increase absorption.

If this antibacterial medication is applied to the eyelids, special care should be taken so that the preparation does not penetrate the eyes, as it could cause glaucoma.

As with all corticosteroids, prolonged application to the face is not recommended.

Appropriate antimicrobial therapy should be used each time inflammatory lesions that have become infected are treated. Any extension of infection requires the withdrawal of topical corticosteroid therapy and systemic administration of antimicrobial agents.

Precautions

In infants and children, long-term treatment with topical corticosteroids should be avoided whenever possible, since adrenal suppression can occur even without occlusion.

In infants, the diaper can act as an occlusive patch and increase absorption. As with all corticosteroids, its application for prolonged periods on the face is not recommended.

If applied to the eyelids, care must be taken that the preparation does not enter the eyes, as glaucoma may occur. Whenever an inflammatory lesion has become infected, appropriate antimicrobial therapy should be indicated.

Any extension of infection requires discontinuation of topical steroid therapy and systemic antimicrobial therapy should be instituted. The bacterial infection is stimulated by heat, and humidity conditions induced by the occlusive bandage, so the skin should be cleaned before applying a new bandage.

Buying Trimovate Cream online

You can buy Trimovate Cream online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this dermatitis medication online, use Pharmacy Planet, a UK pharmacy you can trust.

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Trimovate cream comes in a tube with 15 grams or 30 grams of cream. This antifungal medication belongs to the group of medicines called topical steroids. "Topical" means it is applied to the skin. Topical steroids reduce the redness and itching of certain skin problems. (Not to be confused with "anabolic" steroids misused by some bodybuilders and administered in the form of tablets or injections). Always on prescription Trimovate cream is indicated for the treatment of eczema and dermatitis of all types.

The active ingredient in this Ezcema and psoriasis medication, Chlobetasone butyrate, is a corticosteroid whose anti-inflammatory action is moderately strong; thus, it is classified in Group 3 of the European Community list of corticosteroids for cutaneous use. It has a very wide margin of safety. Under conditions that predispose to maximum percutaneous absorption, Chlobetasone butyrate has a minimal effect on the hypothalamic-pituitary-adrenal cortical axis.

Clinical pharmacology studies carried out in animals and man have revealed the particularly high therapeutic index of this drug; In addition to good anti-inflammatory activity, a very low incidence of local and systemic side effects is observed, compared to other corticosteroids.

Trimovate cream is used to treat inflamed skin. Inflammation of the skin is often caused by bacteria or fungi, or a combination of these. Trimovate kills different types of bacteria and fungi, effectively treating the cause of the problem. Trimovate cream ensures that the skin is less red and swollen and also reduces symptoms such as pain and itching. This medication is increasingly prescribed for skin rashes, certain forms of acne, and infected eczema.

Follow these instructions unless your doctor has given you different directions. Remember to take your medicine. Your doctor will indicate the duration of your treatment with Trimovate cream.  The usual dose is an application of a small amount of Trimovate cream on the affected area up to four times a day until there are an improvement and the application frequency. After washing your hands, apply the correct amount of cream to the affected areas of the skin until its disappearance. Unless used for treating hands, wash them again after applying the cream. Anyone who helps apply the cream should do the same or use disposable plastic gloves.

If in doubt, consult a doctor or pharmacist.

Using when pregnant

The application of topical steroids in pregnant animals can cause abnormalities in fetal development.

The relevance of these findings in humans has not been proven, however, topical steroids should not be used in pregnancy. Eg in large quantities or for long periods.

Like all medicines, Trimovate side effects can occur. At the application site, local allergic reactions such as redness, itching, rash, hives, local burning of the skin, and allergic contact dermatitis, which may resemble symptoms of the skin condition being treated.

When large areas of the body are treated with Trimoovate cream, there may be a deletion transient adrenal. Local atrophic changes, changes in color, amount of hair, and exacerbation of the symptoms. If any other adverse reaction not described above is observed, consult your doctor or pharmacist.

Warnings and precautions

Long-term continued topical corticosteroid therapy in children and infants should be avoided whenever possible, as adrenal suppression may occur even without occlusion. In infants, the diaper can act as an occlusive dressing and increase absorption.

If this antibacterial medication is applied to the eyelids, special care should be taken so that the preparation does not penetrate the eyes, as it could cause glaucoma.

As with all corticosteroids, prolonged application to the face is not recommended.

Appropriate antimicrobial therapy should be used each time inflammatory lesions that have become infected are treated. Any extension of infection requires the withdrawal of topical corticosteroid therapy and systemic administration of antimicrobial agents.

Precautions

In infants and children, long-term treatment with topical corticosteroids should be avoided whenever possible, since adrenal suppression can occur even without occlusion.

In infants, the diaper can act as an occlusive patch and increase absorption. As with all corticosteroids, its application for prolonged periods on the face is not recommended.

If applied to the eyelids, care must be taken that the preparation does not enter the eyes, as glaucoma may occur. Whenever an inflammatory lesion has become infected, appropriate antimicrobial therapy should be indicated.

Any extension of infection requires discontinuation of topical steroid therapy and systemic antimicrobial therapy should be instituted. The bacterial infection is stimulated by heat, and humidity conditions induced by the occlusive bandage, so the skin should be cleaned before applying a new bandage.

You can buy Trimovate Cream online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this dermatitis medication online, use Pharmacy Planet, a UK pharmacy you can trust.

Frequently Asked Questions

No, Trimovate should not be used on the face or around your eyes unless it has been prescribed specifically for this purpose. Facial skin, especially around the eyes, is much thinner than skin elsewhere on the body, making it more susceptible to side effects caused by Trimovate. This includes skin thinning and further irritation from the steroid element in Trimovate. If this medicine comes in contact with your eyes, rinse immediately with clean water. Your healthcare professional can advise on treatments better suited to facial skin or the eye area.

Trimovate is not recommended for conditions such as nappy rash or skin conditions in babies or children. If it is prescribed, it is usually to be used for a very short duration, as children’s skin is thinner and susceptible to side effects. For nappy rash, milder medications such as barrier creams or even 1% hydrocortisone are more appropriate.

Trimovate should be used for no longer than 7 to 10 days, unless your healthcare professional advises otherwise. Do not use this medication longer than necessary, as this can increase your risk of skin thinning, antibiotic resistance, or fungal overgrowth. Once symptoms such as inflammation and infection have been cleared, you can discontinue the use of this medication.

Yes, using a non-scented, chemical-free emollient or moisturiser alongside Trimovate can support skin hydration and repair. Ensure that you apply Trimovate first and allow it to fully absorb into the affected area for at least 30 minutes before applying moisturiser or barrier cream.

Trimovate can be used to treat mixed fungal and bacterial skin infections, particularly where inflammation is also present. It is commonly prescribed for Candida, staphylococcal infections, and secondarily infected eczema or dermatitis. It is not suitable for viral infections, such as cold sores or shingles. Your healthcare professional can recommend the most appropriate treatment based on your specific condition.

If you miss an application, use Trimovate as soon as you remember. If it is nearly time for your next dose, skip the missed application and continue as usual. Doubling your dose and using more medicine than necessary can make you susceptible to side effects. To achieve the best results, maintain consistency with your treatment. If symptoms return due to missed applications, consult your healthcare professional.

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Review By

GURDEV SEHMI

Last Updated On : Mar 13 2026

BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead

GPhC Number: 2050925

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Authored By

GURDEV SEHMI

Last Reviewed On : Mar 23 2026

BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead

GPhC Number: 2050925