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About Trimethoprim Tablets
Trimethoprim is an antibiotic used to treat bladder (cystitis) and urinary tract infections (UTIs). It is included on the World Health Organization's List of Essential Medicines.
Taking a three day course of Trimethoprim will clear most bladder and urinary tract infections. However, if your symptoms have not improved once you have completed your medication, you should seek advice from your GP.
Most cases of cystitis or UTIs are caused by E.coli, which originates in your gut. Trimethoprim does not kill E.coli. Instead, it stops bacterial DNA synthesis, meaning that the bacteria cannot replicate. This allows your immune system to destroy the infecting bacteria until they are eradicated and your infection is resolved.
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What is Trimethoprim?
How does it work?
What are the benefits of taking it?
Trimethoprim is an antibiotic. This medication prevents protein production in bacteria and causes them to die. The active substance is absorbed into the blood and thus reaches the inflamed tissues and urine. Trimethoprim can only be obtained by prescription.
Doctors prescribe trimethoprim as an antibiotic treatment for various infections, such as:
Cystitis in women and other urinary tract infections. This medication can also be used to prevent recurrent bladder infections; Respiratory infections, such as pneumonia, Middle ear infections, sinus infections, and acute bronchitis.
The active substance trimethoprim works quickly. After a few days, you will already notice that inflammatory reactions, such as pain, fever, and a general feeling of being unwell, have subsided.
How do I use it?
Its dosage
Trimethoprim is available in different strengths. The doctor determines which force best suits your symptoms. Unless the doctor directs otherwise, the generally recommended dose of trimethoprim is as follows:
- Adults and children from 12 years: 200 mg twice a day. If you have a bladder infection, your doctor may recommend that you take 300 mg once a day.
- A different dosage recommendation applies to children under the age of 12. Follow the recommended dose and read the package leaflet before taking it.
Side effects & precautions
Seek emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of the face, lips, tongue, or throat.
Call your doctor immediately if you have:
- severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose)
- pale, gray, or bluish skin
- fever, weakness
- sore or swollen tongue
- easy bruising, purple or red spots under the skin
- rash, no matter how mild it is
- high potassium level - nausea, weakness, tingling sensation, chest pain, irregular heartbeat, loss of movement.
Common side effects may include:
- vomiting, diarrhea, stomach pain
- rash, itching
- swelling on your tongue
Interactions
Antibiotics can react with other medications and affect their effectiveness. Inform your doctor during the consultation of any other medicine you are using. Never use more than one product or medication for cystitis unless your doctor tells you to.
If you are taking any of the following treatments, you may not be able to use Trimethoprim, or only be able to use it under medical supervision: repaglinide, procainamide, digoxin, diuretics, rifampin, anticoagulants, phenytoin, pyrimethamine, dapsone or immunosuppressant drugs.
Resistance
Bacterial resistance to trimethoprim may be the result of a reduction in cell permeability, overproduction of the enzyme dihydrofolate reductase, or the production of a conformationally reduced reductase with decreased affinity for the antibiotic. Said forms of resistance can appear by mutation or, more frequently, by the intervention of resistant plasmid-encoded reductases.4 These reductase enzymes can be encoded within the transposons of conjugated plasmids, characterized by showing a wide range of microbial hosts. This would explain the rapid and extensive spread of resistance to trimethoprim among numerous bacterial species.
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