Sildenafil/Viagra

Sildenafil contains the active substance sildenafil which belongs to a group of medicines called phosphodiesterase type 5 inhibitors (PDE5). It works by dilating the blood vessels of the penis, allowing the influx of blood when sexually stimulated. Sildenafil will only help you get an erection if you are sexually stimulated.

Sildenafil is an orally administered therapy for the treatment of erectile dysfunction. In conditions

normal, that is, with sexual stimulation, restores impaired erectile function by increasing blood flow to the penis. The physiological mechanism responsible for the erection of the penis involves the release of nitric oxide (NO) in the corpora cavernosa during sexual stimulation. Nitric oxide activates the guanylate cyclase enzyme, leading to increased levels of cyclic guanosine monophosphate (cGMP), which produces a relaxation of the smooth muscle in the corpora cavernosa of the penis, allowing the influx of blood.

Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5).

the corpora cavernosa, where PDE5 is responsible for the degradation of the cGMP. Sildenafil acts on the peripheral level above the erection. Sildenafil does not have a direct relaxing effect on the bodies. When the NO / cGMP pathway is activated, as occurs during sexual stimulation, the inhibition of Sildenafil PDE5 causes increased cGMP levels in the corpora cavernosa. So, sexual stimulation is necessary for sildenafil to produce its beneficial pharmacological effects planned.

Sildenafil uses include being indicated for the treatment of (ED problems) erectile dysfunction in adult men, sometimes called impotence. This happens when a man cannot obtain or maintain a firm erection, suitable for satisfactory sexual activity.

Always use this medicine exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again. The recommended starting Sildenafil dosage is 50 mg.

You should not take sildenafil more than once a day.

Do not take sildenafil coated tablets together with medicines containing sildenafil in orodispersible tablets.

You should take sildenafil about an hour before you plan to have sex. Swallow the tablet without chewing with a glass of water.

If you notice that the action of sildenafil is too strong or weak, tell your doctor or pharmacist.

Sildenafil will only help you get an erection if you are sexually stimulated. The time it takes for sildenafil to work varies from person to person, generally ranging from half an hour to one hour. The effect of sildenafil may be delayed if you take it with a large meal.

In the event that sildenafil does not help you to get an erection or if the erection is not maintained long enough to complete the sexual act, consult your doctor. If you take more Sildenafil than you should.

You may experience an increase in side effects and their severity. Doses greater than 100 mg do not increase efficacy.

Like all medicines, this ed treatment medication can cause side effects, although not everybody gets them. The reported side effects associated with the use of sildenafil are generally mild to moderate in intensity and of short duration.

If you experience any of the following serious side effects, stop taking sildenafil and seek medical attention immediately:

An allergic reaction occurs infrequently (which can affect up to 1 in 100 people).

• Symptoms include sudden wheezing, shortness of breath or dizziness, swelling of the eyelids, face, lips, or throat.

Chest pains, this occurs infrequently:

If they appear during or after sexual intercourse:

• Sit in a semi-sitting position and try to relax.
• Do not use nitrates to treat chest pain.
• Prolonged and sometimes painful erections, this occurs rarely (may affect up to 1 in 1,000 people).
• If you have an erection that lasts more than 4 hours, you should contact your doctor immediately.

Sudden decrease or loss of vision - this occurs rarely.

Serious skin reactions, this occurs rarely.

Symptoms may include severe peeling and swelling of the skin, gallbladders of the mouth, genitals, and around the eyes, in addition to fever.

Seizures or fits, this occurs rarely.

The following section details more of the known Sildenafil side effects and their frequency.

Very common (may affect more than 1 in 10 people):

• Headache

Common (may affect up to 1 in 10 people):

• sickness
• facial redness
• overheating (symptoms include a sudden sensation of heat in the upper body)
• indigestion
• abnormal color perception, blurred vision, visual impairment
• nasal congestion
• dizziness

Uncommon (may affect up to 1 in 100 people):

• vomiting
• rashes
• eye irritation, eye effusion / red eyes, eye pain, flashing light vision, visual clarity, sensitivity to light, watery eyes
• palpitations, fast heartbeat
• high blood pressure, low blood pressure
• Muscle pain
• feeling sleepy
• reduced touch sensation
• Vertigo
• ringing in the ears
• dry mouth
• blockage or congestion of the sinuses, inflammation of the lining of the nose (symptoms include runny nose, sneezing, and nasal congestion)
• pain in the upper abdomen, gastroesophageal reflux disease (heartburn is among the symptoms)
• blood present in urine
• pain in arms or legs
• nosebleed
• warmth sensation
• feeling tired.

Rare (may affect up to 1 in 1,000 people):

• fading
• stroke, heart attack, irregular heartbeat
• transient decrease in blood flow to some parts of the brain
• A feeling of tightness in the throat, numbness of the mouth
• bleeding from the back of the eye, double vision, decreased visual acuity, abnormal sensation in the eye, swelling of the eye or eyelid, small particles or spots in the vision, the vision of halos around the lumen, dilation of the pupil of the eye, color change of the white part of the eye
• bleeding from the penis
• presence of blood in semen
• dry nose
• swelling inside the nose
• feeling irritable
• sudden decrease or loss of hearing.

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