Sildenafil/Viagra

Sildenafil contains the active substance sildenafil which belongs to a group of medicines called phosphodiesterase type 5 inhibitors (PDE5). It works by dilating the blood vessels of the penis

Sildenafil is an orally administered therapy for the treatment of erectile dysfunction.

The physiological mechanism responsible for the erection of the penis involves the release of nitric oxide (NO) in the corpora cavernosa during sexual stimulation. Nitric oxide activates the guanylate cyclase enzyme, leading to increased levels of cyclic guanosine monophosphate (cGMP), which produces a relaxation of the smooth muscle in the corpora cavernosa of the penis, allowing the influx of blood.

Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). The corpora cavernosa, where PDE5 is responsible for the degradation of the cGMP. Sildenafil acts on the peripheral level above the erection. Sildenafil does not have a direct relaxing effect on the bodies. When the NO / cGMP pathway is activated, as occurs during sexual stimulation, the inhibition of Sildenafil PDE5 causes increased cGMP levels in the corpora cavernosa. So, sexual stimulation is necessary for sildenafil to produce its beneficial pharmacological effects planned.

Sildenafil uses include being indicated for the treatment of (ED problems) erectile dysfunction in adult men, sometimes called impotence. This happens when a man cannot obtain or maintain a firm erection

Always use this medicine exactly as your doctor or pharmacist has told you. If in doubt

Like all medicines, this ed treatment medication can cause side effects, although not everybody gets them. The reported side effects associated with the use of sildenafil are generally mild to moderate in intensity and of short duration.

If you experience any of the following serious side effects, stop taking sildenafil and seek medical attention immediately:

An allergic reaction occurs infrequently (which can affect up to 1 in 100 people).

• Symptoms include sudden wheezing, shortness of breath or dizziness, swelling of the eyelids, face, lips, or throat.

Chest pains, this occurs infrequently:

If they appear during or after sexual intercourse:

• Sit in a semi-sitting position and try to relax.
• Do not use nitrates to treat chest pain.
• Prolonged and sometimes painful erections, this occurs rarely (may affect up to 1 in 1,000 people).
• If you have an erection that lasts more than 4 hours, you should contact your doctor immediately.

Sudden decrease or loss of vision - this occurs rarely.

Serious skin reactions, this occurs rarely.

Symptoms may include severe peeling and swelling of the skin, gallbladders of the mouth, genitals, and around the eyes, in addition to fever.

Seizures or fits, this occurs rarely.

The following section details more of the known Sildenafil side effects and their frequency.

Very common (may affect more than 1 in 10 people):

• Headache

Common (may affect up to 1 in 10 people):

• sickness
• facial redness
• overheating (symptoms include a sudden sensation of heat in the upper body)
• indigestion
• abnormal color perception, blurred vision, visual impairment
• nasal congestion
• dizziness

Uncommon (may affect up to 1 in 100 people):

• vomiting
• rashes
• eye irritation, eye effusion / red eyes, eye pain, flashing light vision, visual clarity, sensitivity to light, watery eyes
• palpitations, fast heartbeat
• high blood pressure, low blood pressure
• Muscle pain
• feeling sleepy
• reduced touch sensation
• Vertigo
• ringing in the ears
• dry mouth
• blockage or congestion of the sinuses, inflammation of the lining of the nose (symptoms include runny nose, sneezing, and nasal congestion)
• pain in the upper abdomen, gastroesophageal reflux disease (heartburn is among the symptoms)
• blood present in urine
• pain in arms or legs
• nosebleed
• warmth sensation
• feeling tired.

Rare (may affect up to 1 in 1,000 people):

• fading
• stroke, heart attack, irregular heartbeat
• transient decrease in blood flow to some parts of the brain
• A feeling of tightness in the throat, numbness of the mouth
• bleeding from the back of the eye, double vision, decreased visual acuity, abnormal sensation in the eye, swelling of the eye or eyelid, small particles or spots in the vision, the vision of halos around the lumen, dilation of the pupil of the eye, color change of the white part of the eye
• bleeding from the penis
• presence of blood in semen
• dry nose
• swelling inside the nose
• feeling irritable
• sudden decrease or loss of hearing.

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