Sandrena Gel is an effective HRT that contains estradiol, which is a synthetic, bioidentical form of the female hormone oestrogen. This HRT gel comes in sachets of 1mg/1g and 500mcg/500mg with 28 sachets per pack.


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Starts at £34.00
Please find below product pricing:
Brand Medicine Strength Size Price
- 500mcg/500g 1 box 34.00
- 500mcg/500g 2 boxes 52.00
- 500mcg/500g 3 boxes 69.00
- 1mg/1g 1 box 34.00
- 1mg/1g 2 boxes 52.00
- 1mg/1g 3 boxes 69.00

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Sandrena Gel is an effective HRT that contains estradiol, which is a bioidentical form of the female hormone oestrogen. This HRT gel comes in sachets of 1mg/1g,( meaning it contains 1mg of estradiol) and 500mcg/500mg, (meaning it contains 0.5mg of estradiol) with 28 sachets per pack. Sandrena and Oestrogel can be prescribed interchangably if there are any stock issues.

People also ask

What is Sandrena Gel?

Sandrena Gel is a smooth-applying HRT containing estradiol, which is a bioidentical form of the female hormone oestrogen. Sandrena Gel works like other hormone replacement therapies, like Oestrogel, when applied topically can replace the deficiency of estrogen as it depletes during menopause. Sandrena Gel aids in relief of menopausal symptoms such as: hot flushes, low mood, headaches, vaginal dryness and irritation, difficulty sleeping, night sweats and reduced sex drive.

How does Sandrena work?

After menopause or after the removal of parts of the female reproductive system, the oestrogen levels in the body begin to decrease which causes unpleasant symptoms to occur within the body.When this gel is applied, it is able to evaporate into the skin quickly, allowing the estradiol to be absorbed into the blood stream. This results in the increase of oestrogel in the body and the reduction of menopausal symptoms.

What are the benefits of Sandrena Gel? 

Sandrena is able to improve the quality of life within women going through menopause due to its help in the reduction of menopausal symptoms. It is easy to apply as it is a topical, fast drying, alcohol based gel.

How do I use Sandrena Gel and what is the dosage? 

Sandrena comes in sachets of 0.5 mg estradiol in 0.5 g of gel, or in sachets of 1 mg estradiol in 1g of gel.
Use the amount of Sandrena gel that your doctor has prescribed. Your doctor will aim to prescribe the lowest dose to treat your symptom for as short as necessary. Speak to your doctor if you think this dose is too strong or not strong enough.

The recommended dose is between 0.5 mg and 1.5 mg of estradiol a day.Use the following number of 0.5 g or 1 g sachets depending on the dose, and the pack size prescribed by your doctor:For a 0.5 mg daily dose: Use one 0.5 g sachet.For a 1 mg daily dose: There are two options. Use one 1 g sachet or use two 0.5 g sachets.

For a 1.5 mg daily dose: There are two options. Use three 0.5 g sachets or use one 0.5 g sachet with one 1 g sachet.

If you are also taking progestagen tablets, take them as your doctor has told you. You will normally have a withdrawal bleed after each course of progestagen.

How to apply the gel
Sandrena should be rubbed gently on dry and clean skin.
It should not be swallowed.

Where to apply the gel
Do not apply the gel to your breasts, face or on irritated skin.
Apply the gel to your lower body or thighs.
Apply the gel to a different side of your body each day.

Follow these instructions:
1. Apply the gel once a day to the skin on your lower body or thighs.
2. Spread the gel over an area 1–2 times the size of your hand.
3. Allow the gel to dry for a few minutes.
4. Wash your hands after applying the gel. Avoid contact of the gel with your eyes. The gel may irritate your eyes.
5. Do not wash the area where you have applied the gel for at least one hour.

Cautions / Side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Stop using the gel and see your doctor straight away, if you notice any of the following serious side effects:

your blood pressure rises
your skin or the whites of your eyes go yellow (jaundice)
you suddenly have migraine-type headaches (see section 2)
you have signs of a blood clot (see section 2)
you get any of the problems listed in section 2.
The following diseases are reported more often in women using HRT compared to women not using HRT:

breast cancer
abnormal growth or cancer of the lining of the womb (endometrial hyperplasia or cancer)
ovarian cancer
blood clots in the veins of the legs or lungs (venous thromboembolism)
heart disease
probable memory loss if HRT is started over the age of 65.
For more information about these side effects, see section 2.

During the first few months of treatment, breakthrough bleeding, spotting and breast tenderness or enlargement can occur. These are usually temporary and normally disappear after continued treatment.

Other side effects

Common (may affect up to 1 in 10 people):

itching of the skin, rash, pain, increased sweating, swollen feet and lower legs
breasts become tender or painful
increase or decrease in your weight
headache, dizziness
tummy pains, feeling sick or being sick, flatulence
bleeding or spotting, menstrual disorder
depression, nervousness, lethargy
hot flushes.
Uncommon (may affect up to 1 in 100 people):

changes to sex drive and mood, anxiety, sleeplessness, apathy, emotional instability, impaired concentration,euphoria, agitation
migraine, delusion, trembling
visual impairment, dry eye
hypertension, superficial phlebitis, purpura
shortness of breath, rhinitis
benign breast or endometrial tumour
increased appetite, high level of cholesterol in the blood
increased heart rate
constipation, digestive disturbance, diarrhoea, rectal disorder
acne, alopecia, dry skin, nail disorder, skin nodule, excessive growth of hair, urticaria (a raised, itchy rash that appears on the skin), painful reddish skin nodules (erythema nodosum)
joint disorders, muscle cramps
increased urinary frequency/urgency, loss of bladder control, urinary tract infection, urine discoloration, haematuria
tender or swollen breast, abnormal growth of the lining of the womb, uterine disorder
tiredness, abnormal laboratory test, weakness, fever, flu syndrome, general feeling of ill health
allergic (hypersensitivity) reaction.
Rare (may affect up to 1 in 1,000 people):

venous thromboembolism
alterations in liver function and biliary flow
contact lense intolerance
menstrual pain
pre-menstrual like syndrome.
Adverse events reported post marketing with frequency not known (cannot be estimated from the available data):

uterine fibroids
hereditary angioedema
cerebral circulatory disorder
, bloating
liver disease causing yellowing of the skin
contact rash, eczema
If you have any of these side effects tell your doctor. The doctor may decide to stop your treatment for a while.


HRT will not prevent memory loss. There is some evidence of a higher risk of memory loss in women who start using HRT after the age of 65. Speak to your doctor for advice.

The following side effects have been reported with other HRTs:

gall bladder disease
probable dementia over the age of 65
various skin disorders:
discolouration of the skin especially of the face or neck known as “pregnancy patches” (chloasma)
rash with target-shaped reddening or sores (erythema multiforme)
purpura due to loss of integrity or function of the vessels (vascular purpura)

How to buy Sandrena Gel online

You can buy Sandrena Gel online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this gel online, use Pharmacy Planet, a UK pharmacy you can trust.