Rectogesic GTN Ointment

Rectogesic is an analgesic ointment that is suitable for anal use. The active substance is glyceryl trinitrate - a vasodilator. ...

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Rectogesic is an analgesic ointment that is suitable for anal use. The active substance is glyceryl trinitrate - a vasodilator. Rectogesic ensures that the bloodstream in the anus widens so that more blood can flow into the tissue. This relieves complaints such as pain and a feeling of oppression.

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What is Rectogesic?

Rectogesic is a rectal ointment containing glyceryl trinitrate as the active substance. Glyceryl trinitrate belongs to a group of drugs called organic nitrates.

How does it work?

The main pharmacological action of glyceryl trinitrate is relaxation of vascular smooth muscle mediated by the release of nitric oxide. When glyceryl trinitrate ointment is applied internally, the internal anal sphincter is relaxed.

Hypertonicity of the internal but not the external anal sphincter is a predisposing factor in the formation of anal fissures. The blood vessels of the anoderm pass through the internal anal sphincter (IAS). Therefore, the hypertonicity of the EAI can thus decrease blood flow and cause ischemia in this region.

The distension of the rectum results in the inhibitory reflex of the anus and the relaxation of the internal anal sphincter. The nerves that mediate this reflex are located in the wall of the abdomen. The release of neurotransmitter NO from nerves of this type has a significant role in the physiology of the internal anal sphincter. Specifically, NO mediates the inhibitory reflex of the anus in man, relaxing the EAI.

A link has been established between EAI hypertonicity and spasm and the presence of an anal fissure. Patients with chronic anal fissure have a significantly higher mean maximum anal pressure at rest than controls, and blood flow in patients with chronic anal fissure was significantly lower than in controls. In patients whose fissures healed after a sphincterotomy, a reduction in anal pressure and improvement in blood flow was demonstrated, providing further evidence of the ischemic nature of anal fissures. The topical application of a NO donor (glyceryl trinitrate) relaxes the anal sphincter, resulting in a reduction in anal pressure and an improvement in blood flow.

What are the benefits of taking it?

The ointment will help alleviate the painful symptoms caused by chronic anal fissures. An anal fissure is a tear in the skin that lines the anal canal. The topical application of glyceryl trinitrate to the anal canal reduces anal pressure and increases blood flow, reducing the sensation of pain.

How do I use it and its dosage?

Administration method

Rectogesic 4 mg/g Rectal Ointment is for rectal use.

Always use this medicine exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again. The recommended dose is approximately 375 mg of ointment (approximately 1.5 mg of glyceryl trinitrate) applied to the anal canal every 12 hours.

The finger can be covered, with plastic film or a finger ring, before applying the ointment. Finger cots can be obtained from your local pharmacy or surgical supply provider and plastic film from a local business. The coated finger is placed next to the line for the 2.5 cm dosage, which appears on the outer carton, and an amount of ointment equivalent to the length of the line is drawn over the end of the finger with light pressure on The tube. Insert the ointment gently into the anal canal with your finger. The finger with ointment should be inserted up to the first knuckle (about 1 cm) inside the anus.

Apply the ointment every twelve hours according to your doctor's instructions and do not exceed the indicated dose. Wash your hands after each use and remove the plastic fingerprint or film (not down the toilet drain).

Treatment may be continued until the pain subsides, or for up to 8 weeks. If pain is not relieved after using Rectogesic, you should consult your doctor again to rule out another cause of pain.

Side effects & precautions

Like all medicines, this cardiovascular medication can cause side effects, although not everybody gets them.

Serious side effects:

  • Anaphylactoid reaction (life-threatening allergic reaction with swelling of the face, lips, tongue or throat, difficulty breathing, shortness of breath, or lipothymia). If you experience any of these symptoms, stop using the ointment, and see a doctor immediately.
  • Allergic skin reactions (potentially serious). If you experience any allergic skin reaction, stop using the ointment, and see a doctor immediately.

Other adverse effects:

Very common (may affect more than 1 in 10 people)

  • Headaches, which can be severe. If you start to get a headache as a side effect, wipe off any remaining ointment. If headaches become bothersome, ask your doctor if you should stop using the medicine.

Common (may affect up to 1 in 10 people)

  • Dizziness
  • Sickness

Uncommon (may affect up to 1 in 100 people)

  • Diarrhea
  • Vomiting
  • Rectal bleeding, rectal disorder
  • Anal discomfort, itching, or burning in the anal canal
  • Fast heart rate or palpitations

Rare (may affect up to 1 in 1,000 people)

  • Dizziness when standing up

Side effects of unknown frequency (frequency cannot be estimated from the available data)

  • Lightheadedness, fainting
  • Low blood pressure
  • Irritation, rash, or pain at the application site

Other known side effects associated with glyceryl trinitrate products (unknown frequency)

  • Hot flushes
  • Unstable angina (chest pain)
  • High blood pressure when stopping treatment
  • Methemoglobinemia (symptoms are bluish/purple discoloration of the skin and shortness of breath)

Buying Rectogesic online.

You can buy Rectogesic online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy Rectogesic Ointment online, use Pharmacy Planet, a UK pharmacy you can trust.

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