Propranolol is a medication that is often prescribed for high blood pressure or palpitations. However, it also works well against ...

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What is Propranolol?

Propranolol contains propranolol hydrochloride which belongs to a group of medicines called beta-blockers. It has effects on the heart and also on other parts of the body.

How does it work?

Propranolol is a competitive antagonist of beta1 and beta2 adrenergic receptors. It does not have agonist activity at beta-adrenergic receptors, but it has a stabilizing activity of the membrane at concentrations exceeding 1-3 mg/liter, although such concentrations are rarely reached during oral treatment. The competitive beta-blockade has been demonstrated in humans by parallel shifting to the right on the heart rate dose-response curve obtained with beta-agonists such as isoprenaline. Like other beta-blockers, propranolol has negative inotropic effects and is, therefore, contraindicated in case of uncontrolled heart failure. Propranolol is a racemic mixture and the active form is the S (-) isomer. With the exception of the inhibition of the conversion of thyroxine to triiodothyronine, the different therapeutic effects are not likely to be increased by some additional secondary property of R (+) propranolol, compared to the racemic mixture.

What are the benefits of taking it?

Propranolol can be used to:

  • Hypertension (high blood pressure)
  • Angina pectoris (chest pain)
  • Some type of arrhythmias (heart rhythm disorders)
  • Protection of the heart after a myocardial infarction (heart attack) Migraine
  • Essential tremor (involuntary and rhythmic tremors)
  • A certain type of thyroid disease (thyrotoxicosis and hyperthyroidism, which is caused by an overactive thyroid gland)
  • Hypertrophic cardiomyopathy (thickening of the heart muscle)
  • Pheochromocytoma (high blood pressure usually due to a tumor near the kidney)
  • Bleeding into the esophagus caused by high blood pressure in the liver

How do I use it and its dosage?

Always take these high blood pressure tablets as directed by your doctor or pharmacist or nurse. If in doubt, consult your doctor or pharmacist again.

Swallow the propranolol tablet with water before meals. It must be swallowed whole. Do not chew. Do not stop taking the medication unless your doctor tells you to.

The following table shows the recommended doses for an adult:

Recommended dose

Hypertension (high blood pressure)

  • Initially, 40 mg two or three times a day, which can be increased to 80 mg per day at weekly intervals.

Angina (chest pain) and tremor

  • Initially, 40 mg two to three times a day, which can be increased to 40 mg per day at weekly intervals.

Protection of the heart after a heart attack

  • Initially, 40 mg four times a day and after a few days switch to 80 mg twice a day.

Migraine

  • Initially, 40 mg two to three times a day, which can be increased to 40 mg per day at weekly intervals.

Arrhythmias (heart rhythm disorders), hyperthyroidism, and thyrotoxicosis (certain thyroid conditions), and hypertrophic cardiomyopathy (thickened heart muscle)

  • 10 to 40 mg three or four times a day.

Pheochromocytoma

  • Preoperative: 60 mg daily
  • Non-operable malignant cases: 30 mg daily

Liver disease due to high blood pressure

  • Initially, 40 mg twice a day, increasing to 80 mg twice a day

Side effects & precautions

Like all medicines, these blood pressure pills can cause side effects, although not everybody gets them. The following side effects may appear when using this medicine:

Common (may affect up to 1 in 10 patients):

  • Cold fingers and toes
  • Slower heart rate
  • Numbness and cramping in the fingers, followed by effusion and pain (Raynaud's syndrome)
  • Sleep disorders / nightmares
  • Fatigue
  • Difficulty breathing

Uncommon (may affect up to 1 in 100 patients):

  • Nausea, vomiting, and diarrhea.

Rare (may affect up to 1 in 1,000 patients):

  • Worsening of respiratory distress, sometimes fatal, if you have or have had asthma or asthmatic complaints in the past.
  • Heart failure worsening heart problems
  • Swelling of the skin that may occur on the face, tongue, larynx, abdomen, or arms and legs (angioedema)
  • Dizziness, especially when getting up
  • Worsening of blood circulation, if you already have poor circulation.
  • Hair loss (Alopecia)
  • Emotional instability
  • Confusion
  • Memory loss
  • Psychosis or hallucinations (mental disorders).
  • Paresthesia (an abnormal sensation, usually tingling or pricking ("pins and needles")
  • Vision disturbances.
  • Dry eyes.
  • Skin rash, including worsening of psoriasis ·

Your medicine can change the number and types of your blood cells, such as reducing the number of platelets (thrombocytopenia) in your blood, which can make it easier for you to bruise and bleed.

Purple spots on the skin (purple).

Very rare (may affect up to 1 in 10,000 patients):

  • Severe muscle weakness (myasthenia gravis)
  • Low blood sugar levels may occur in diabetic and non-diabetic patients, including newborns, young children, and children, the elderly, patients with artificial kidneys (hemodialysis), or patients taking diabetes medications. It can also occur in patients who are fasting or who have recently fasted or who have long-term liver disease.
  • Excessive sweating

Buying Propranolol online.

You can buy propranolol tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this high blood pressure treatment medication online, use Pharmacy Planet, a UK pharmacy you can trust.

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