Progynova is a medication that reduces menopausal discomforts, such as hot flashes, sweat attacks, menstrual disorders, sleep disorders, and mood changes. It is a hormone replacement therapy. The active substance in Progynova is estradiol. This is a female hormone (estrogen), which is created in the ovaries. If a woman experiences menopause, she will no longer create this hormone. This can lead to discomfort. Progynova fills the estrogen deficit, ensuring that discomfort is lessened.


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Starts at £30.00
Please find below product pricing:
Brand Medicine Strength Size Price
- 1mg 252 Tablets 84.00
- 2mg 84 Tablets 30.00
- 2mg 168 Tablets 58.00
- 2mg 252 Tablets 84.00
- 1mg 84 Tablets 30.00
- 1mg 168 Tablets 58.00

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Progynova is a medication that reduces menopausal discomforts, such as hot flashes, sweat attacks, menstrual disorders, sleep disorders, and mood changes. It is a hormone replacement therapy.

People also ask

What is Progynova?

Progynova is indicated in hormone replacement therapy (HRT) for the treatment of menopausal symptoms (period of time in which reproductive function and menstruation cease in a woman), natural or surgically caused (castration), e.g. ex. hot flushes, night sweats, urogenital disorders (atrophic vulvovaginitis). If you have your uterus intact, the administration of estrogens, as in the case of Progynova, must always be accompanied by the sequential administration of a progestogen.

How does it work?

The active substance, synthetic 17-estradiol, is chemically and biologically identical to human endogenous estradiol. It replaces the loss of estrogen production that occurs during menopause and relieves menopause symptoms. Ovulation is not inhibited during the use of Progynova, and endogenous hormone production is hardly affected.

What are the benefits of taking it?

Progynova is indicated as Hormone Replacement Therapy (HRT). Contains estrogen, a female hormone. After menopause, the ovaries stop producing this hormone. Progynova is used to treat menopausal symptoms such as hot flashes, night sweats, or vaginal dryness. Progynova is also used in the prevention of osteoporosis in postmenopausal women who are at high risk for fractures and who cannot use other osteoporosis treatments.

How do I use it and its dosage?

Always use Progynova patches exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again.

Your doctor should always consider giving the lowest dose and the shortest duration of treatment. If you think that Progynova's action is too strong or weak, tell your doctor or pharmacist.

Adult women, including the elderly.

If you are hysterectomised (your uterus is partially or completely removed), you can start treatment at any time.

If you have an intact uterus and still have menstrual cycles, treatment should start within 5 days after the start of menstruation by combining Progynova with a progestogen.

If you do not have menstrual periods, your menstrual periods are very infrequent, or you are in the postmenopausal period, treatment can be started by combining Progynova with a progestogen at any time, provided that a possible pregnancy.


Unless the doctor tells you otherwise, treatment is started by taking two Progynova 1 mg tablets without chewing daily, after a meal. After a certain time, your doctor may reduce the dose to one daily 1 mg tablet.

After 6 months of treatment, it is recommended to stop the medication to check if the discomfort still persists.


After each 20-day treatment cycle, the coated tablets may be paused, usually for a week or less (cyclic HRT), or the coated tablets may be continued without interruption (continuous HRT). In the latter case, a new container is started directly at the end of the previous one.

Combined guideline:

If you have an intact uterus, the concomitant use of an appropriate progestogen is recommended for 10-14 days every 4 weeks (combined sequential HRT) or with each estrogen-coated tablet (continuous combined HRT).

Your physician should make an adequate provision to facilitate and ensure proper adherence to the recommended combination regimen.

The tablets should be taken without chewing, with some liquid.

It does not matter what time of day you take the tablet, but once you have selected a specific time, you should keep it every day.

Adding a progestogen is not recommended in hysterectomised women unless there is a previous diagnosis of endometriosis.

Change from other HRT treatments (cyclical, continuous sequential, or combined continuous):

if you switch from other HRT treatments, you must end your treatment cycle before starting Progynova treatment.

If you think that Progynova's action is too strong or weak, tell your doctor or pharmacist.

Side effects & precautions

Like all medicines, this medicine can cause side effects, although not everybody gets them. For more information, please refer to the Patient information leaflet. The following diseases occur more frequently in women who use HRT compared to women who do not take HRT:

  • breast cancer
  • abnormal growth or cancer of the inner wall of the uterus (endometrial hyperplasia or cancer)
  • ovarian cancer
  • blood clots in the veins of the legs or lungs (venous thromboembolism)
  • coronary heart disease
  • stroke
  • probable memory loss if HRT has been started after 65 years of age.

The possible adverse effects are listed below, according to the part of the organism that they affect and their frequency of appearance, which have been reported in users of different oral preparations of hormone replacement therapy.

Common side effects (may affect up to 1 in 10 people):

  • Weight gain, weight decrease
  • Headache (headache)
  • Abdominal pain, nausea
  • Skin rash, itching (itching)
  • Vaginal bleeding including spotting

Uncommon Progynova side effects (may affect up to 1 in 100 people):

  • Hypersensitivity (allergic) reaction
  • Depressive mood
  • Dizziness
  • Visual disturbances
  • Palpitations
  • Dyspepsia (difficult digestion)
  • Erythema nodosum (inflammation of the skin with the appearance of nodules, usually located on the legs)
  • Urticaria
  • Breast pain, tenderness in the breasts
  • Edema (fluid retention)

Rare Progynova side effects (may affect up to 1 in 1,000 people):

  • Anxiety, increased libido (sexual desire), decreased libido
  • Migraine
  • Intolerance to contact lenses
  • Bloating, vomiting
  • Hirsutism (excessive hair growth), acne
  • Muscle cramps
  • Dysmenorrhea (painful menstruation), vaginal discharge, premenstrual-like syndrome, breast enlargement
  • Fatigue

Buying Progynova online.

You can buy Progynova Tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this menopause treatment medication online, use Pharmacy Planet, a UK pharmacy you can trust.