Ovestin is a hormone replacement therapy. Ovestin is used by women requiring HRT. This medicine is a cream containing an active natural female sex hormone called estriol, which acts locally within the vagina. The cream may not work immediately and improvement may take a few days or weeks. Ovestin can be used to relieve vaginal symptoms resulting from a lack of oestrogen, and both before and after surgery of the vagina to encourage wound healing. Ovestin can be started immediately if you have never previously used HRT, are switching from an HRT where you do not have menstrual periods, or your ovaries or womb (uterus) have been removed.