Novofem is medicine for menopausal symptoms. The active ingredients of Novofem estradiol (an estrogen hormone) and norethisterone (a luteal hormone) ...

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What is Novofem?

Novofem is a form of estrogen, a female sex hormone that regulates many processes in the body. Norethindrone is a form of progesterone, an important female hormone to regulate ovulation and menstruation. Novofem is a combination medicine used to treat menopausal symptoms, such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Novofem and norethindrone can also be used for purposes not mentioned in the Novofem guide.

How does it work?

Estradiol: The active substance, synthetic 17b-estradiol, is chemically and biologically identical to endogenous human estradiol. It replaces the loss of estrogen production that occurs during the postmenopause of women and alleviates the symptoms of menopause. Estrogens prevent bone loss due to menopause or ovariectomy.

Norethisterone acetate: Synthetic progestin. Estrogens promote the growth of the endometrium, whereby unopposed estrogens increase the risk of hyperplasia and endometrium cancer. Adding a progestogen reduces the risk of endometrial hyperplasia induced by estrogens in non-hysterectomised women.

What are the benefits of taking it?

Novofem Tablet uses and benefits include being indicated for the treatment of menopausal symptoms. This includes:

  • Hot flushes;
  • Excessive sweating, night sweats;
  • Vaginal dryness and dry mouth and/or eyes;
  • Anxiety;
  • Mood swings or depression
  • Sleep disorders;
  • Decreased sexual desire;
  • Bone loss (osteoporosis).

In addition to estradiol (to reduce menopausal symptoms), Novofem also contains norethisterone. This substance protects the uterus from the side effects that can be caused by the administration of estradiol. Novofem is particularly suitable for women who still have (irregular) periods and whose uterus is still present.

How do I use it and its dosage?

Always take these HRT tablets exactly as your doctor tells you. Consult your doctor or pharmacist if you have questions.

If you are not taking any other hormone replacement therapy, treatment with Novofem can start it on the day that you consider convenient. If you are already taking other types of hormone replacement therapy, your doctor will tell you when to start the Novofem treatment.

One tablet will be taken once a day, at approximately the same time each day.

Each box contains 28 tablets

  • Days 1-16 Take one red tablet every day for 16 days
  • Days 17-28 Take one white tablet every day for 12 days

Take the tablets with a glass of water.

Once you have finished the box, start a new one by continuing the treatment without interruption.

Menstruation (period) bleeding usually occurs at the beginning of a new box.

Check with your doctor if you do not show improvement after 3 months of treatment. You should only continue treatment when the benefit outweighs the risk.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using Novofem and norethindrone.

Your doctor should check your progress regularly (every 3 to 6 months) to determine if you should continue with this treatment. Self-examine your breasts monthly for lumps and get a mammogram every year while using Novofem and norethindrone.

Store at room temperature, away from moisture, heat, and light.

Side effects & precautions

Like all medicines, this hormone replacement therapy menopause medication can cause side effects, although not all people suffer from them.

The following diseases occur more often in women using HRT in Comparison with women who do not use HRT:

  • Breast cancer
  • abnormal growth or cancer of the lining of the uterus (endometrial hyperplasia or cancer)
  • ovarian cancer
  • blood clots in the veins of the legs or lungs (venous thromboembolism)
  • heart disease
  • stroke
  • probable memory loss if HRT starts after 65 years of age

Hypersensitivity/allergy (rare side effect affecting 1 - 10 users due to every 1,000)

Although rare, hypersensitivity / allergy may occur: Signs of hypersensitivity/allergy may include one or more of the following symptoms: hives, itching, swelling, difficulty breathing, low blood pressure (pale and cold skin, rapid heart rate), feeling dizzy, sweating, which may be signs of reaction/shock anaphylactic. 

Very common Novofem side effects (may affect more than 1 in 10 people)

  • Headache
  • Breast pain

Common effects (may affect up to 1 in 10 people)

  • Increased blood pressure and worsening hypertension
  • Vaginal yeast infection (eg, yeast infection)
  • Dizziness, insomnia, depression
  • Dyspepsia (indigestion), abdominal pain, flatulence
  • Nausea (dizziness)
  • Rash, itching
  • Vaginal bleeding
  • Aggravation of uterine fibroids (benign tumor of the uterus)
  • Edema (swelling of hands, wrists, and feet)
  • Weight gain

Infrequent effects (may affect up to 1 in 100 people)

  • Migraine
  • Libido changes (change in sexual desire)
  • Peripheral embolism and thrombosis (blood clots)
  • Vomiting (dizziness)
  • Gallbladder disease or gallstones

Hair loss (alopecia)

  • Muscle cramps

Rare effects (may affect up to 1 in 1,000 people)

  • Allergic reactions
  • Nervousness
  • Vertigo (dizziness)
  • Diarrhea
  • Swollen abdomen
  • Acne
  • Uterine fibroma (benign tumor of the uterus)

Buying Novofem online.

You can buy Novofem tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this HRT medication online, use Pharmacy Planet, a UK pharmacy you can trust.

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