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Moduretic is a prescription medicine used in the treatment of high blood pressure also known as hypertension, oedema, or heart failure. The medicine consists of two water pills or diuretics called amiloride and hydrochlorothiazide.

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What is Moduretic?

Moduretic is a prescription medicine used in the treatment of high blood pressure also known as hypertension, oedema, or heart failure. The medicine consists of two water pills or diuretics called amiloride and hydrochlorothiazide. These diuretics get rid of extra salt and water in the body which also helps in maintaining normal levels of potassium in the blood.

How Does Moduretic Work?

Moduretic is a combination of two medications, amiloride and hydrochlorothiazide, which belong to the group of drugs classified as diuretics or water pills. Moduretic is a potassium sparing diuretic that increases the amount of salt and water removed by the kidneys from the blood. This helps the body get rid of excess fluid while maintaining healthy amounts of potassium. Hydrochlorothiazide in particular is a thiazide diuretic that prevents the reabsorption of salt into the body to prevent fluid from building up.

What Are the Benefits of Taking Moduretic?

Some benefits of Moduretic are:

  • Reduces the amount of excess fluid in the body for people who suffer from swollen feet, ankles and legs (oedema).
  • Prevents fluid build-up in people who have liver disease that causes fluid accumulation in the stomach.
  • Helps maintain normal levels of Potassium in the blood.
  • Reduces high blood pressure.

How Do I Use Moduretic?

Moduretic is an oral medication that is to be taken orally. The amount and strength of dosage depend on your medical condition. It is recommended to take the dose at the same time each day as it may help you become consistent.

The medicine needs to be taken exactly how your doctor has prescribed it. If you are to take a single dose per day, it is recommended to have it in the morning. If you are taking more than one dose per day, the last dose should be taken in the early evening unless your doctor recommends otherwise. Since Moduretic can make you pass more urine, taking the last dose in the early evening will help you sleep undisturbed later at night.

Moduretic Tablets Dosage

The dosage of Moduretic will be prescribed by your doctor according to your condition and several other factors. The starting dosage for conditions such as high blood pressure and heart failure is half a tablet each day. Your doctor will tell you how many tablets you need to take each day and monitor your progress to increase or decrease the dosage accordingly. Generally, you should not take more than 2 Moduretic tablets in a single day unless your doctor says otherwise.

Needs to be taken every day according to your doctor’s recommendations. Since Moduretic maintains blood pressure and does not cure it, stopping the intake suddenly is not recommended. In case of a missed dose, you can take it within the same day or wait for the next day’s dose. Taking two doses in a day is not suitable.

Moduretic Precautions and Side Effects

Side Effects

Like all medicines, Moduretic may have some non-serious side effects. However, it can be concerning if these side effects worsen or persist over time. Some common side effects include:

  • Headache
  • Nausea and vomiting
  • Loss of appetite
  • Abdominal pain
  • Diarrhoea
  • Gas

Some people may face more serious side effects including:

  • Severe symptoms of dehydration such as extreme dryness in mouth, thirst, weakness, severe dizziness, fainting, seizures and more.
  • Yellowing of eyes or skin, persistent nausea, symptoms of kidney problems, decrease in vision and eye pain.
  • Signs of a severe allergic reaction such as rashes, swelling of the face, tongue or throat, dizziness and difficulty breathing.

This list may not contain all the possible side effects, if you notice any of these extreme symptoms or other severe reactions, contact your physician right away.


Before taking Moduretic you should inform your doctor if you:

  • Have high levels of cholesterol, uric acids or triglycerides.
  • Suffer from Systemic Lupus Erythematosus
  • Take digitalis
  • Are a senior citizen
  • Receive fluids through a tube inserted into your veins
  • Have suffered from skin cancer
  • Are allergic to the active ingredients amiloride and hydrochlorothiazide or any other inactive ingredients.
  • Have an untreated mineral imbalance like high potassium or low sodium levels.
  • Suffer from diabetes, kidney disease, or gout.

Always inform your doctor about your medical history before taking the medicine to ensure protection from adverse effects.


Some precautions to keep in mind while taking Moduretic are:

  • Moduretic may cause dizziness which is worsened by consuming alcohol or marijuana. Do not engage in activities that require alertness such as driving or operating heavy machinery until you feel stable enough to do them safely.
  • The medication can result in a significant loss of body fluid due to nausea, sweating and diarrhoea. Make sure to consume a lot of fluids to prevent dehydration. Contact your doctor in case of adverse effects.
  • Moduretic may increase your sensitivity to the sun and the risk of skin cancer over time. Limit your time in the sun and avoid tanning booths to prevent sunburn or other conditions caused by sun exposure. Contact your physician if you notice any rashes, skin lesions, or other skin conditions.
  • If you suffer from diabetes, Moduretic may affect your blood sugar. Monitor your blood sugar regularly.
  • If you wish to consume potassium supplements or salt substitutes while on Moduretic, consult your doctor as this medicine can affect potassium levels in the blood.
  • Breastfeeding mothers should consult their doctors to weigh the risks and benefits of medicine as one of the active ingredients is capable of passing through breast milk.

High-Risk Groups

High-risk groups for Moduretic include:

  • The elderly
  • People allergic to the active ingredients hydrochlorothiazide and amiloride hydrochloride or other inactive ingredients.
  • People suffering from diabetes
  • Pregnant women and breastfeeding mothers.
  • Individuals suffering from kidney or liver disease.
  • People with ah high potassium intake through supplements or food.
  • Individuals with Addison’s disease.

Moduretic Indications

Moduretic is indicated in the treatment of:

  • High blood pressure or hypertension
  • Heart failure
  • Oedema

How Do I Buy Moduretic Online?

You can conveniently buy Moduretic online in the UK from [this website] after filling out a prescription form. The high blood pressure medication should be taken exactly as directed by your physician. Any misuse of the drug can have potentially harmful effects on your health.

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