Mezavant/Mesalazine

Mezavant tablets are indicated to help keep you free from new flares of ulcerative colitis. Ulcerative colitis is an inflammatory bowel disease in which the lining of the intestine is inflamed and develops many tiny breaks in its surface (ulcers) that can bleed. Mezavant belongs to a group of medicines called intestinal anti-inflammatory drugs that help reduce inflammation and painful symptoms.

Mesalazine is the active component of sulfasalazine, used for the treatment of ulcerative colitis and Crohn's disease.

The therapeutic action of mesalazine seems to be due to the local effect exerted on inflamed intestinal tissue, rather than a systemic effect. There is information to suggest that the severity of colonic inflammation in patients with ulcerative colitis treated with mesalazine is inversely correlated with mucosa concentrations of mesalazine.

In patients with inflammatory bowel disease, there is an increase in the migration of leukocytes, an abnormal production of cytokines, an increase in the production of metabolites of arachidonic acid, particularly leukotriene B4, and an increase in the formation of free radicals in the inflamed intestinal tissue. The mechanism of action of mesalazine is not fully understood although mechanisms such as activation of the γ-form of peroxisome proliferation-activating receptors (PPAR-γ) and inhibition of nuclear factor kappa B (NF-κB) of the mucosa are involved. intestinal. Mesalazine has pharmacological effects both in vivo and in vitro that inhibit leukocyte chemotaxis, decrease cytokines and leukotriene formation, and eliminate free radical formation. It is currently unknown which, if any, of these mechanisms has a predominant role in the clinical efficacy of mesalazine.

The risk of colorectal cancer (RCC) is slightly increased in ulcerative colitis.

The effects of mesalazine observed in experimental models and patient biopsies support the role of mesalazine in the prevention of RCC associated with colitis, with down-regulation of the dependent and independent signals of inflammation related to the development of RCC associated with colitis. However, meta-analysis data, including reference and non-reference populations, provide inconsistent clinical information regarding the benefit of mesalazine on the risk of carcinogenesis associated with ulcerative colitis.

Mezavant uses include being indicated for the treatment of mild to moderately active ulcerative colitis (a chronic inflammatory bowel disease). The active substance is mesalazine from the group of aminosalicylates. Mesalazine is believed to alleviate inflammation in the intestine by blocking the enzyme cyclooxygenase and inhibiting the production of prostaglandins in the intestinal wall.

Always take this medicine exactly as your doctor or pharmacist has told you. If you have any questions, ask your doctor or pharmacist again.

The recommended mezavant doage is:

Adults:

To help you stay free of more colitis outbreaks, your doctor may usually prescribe 2 grams of mesalazine per day, given as 4 tablets once a day.

Use in children and adolescents (aged 6 years and over):

For children and adolescents, the dose will be calculated by your doctor based on body weight. The recommended dose in children and adolescents with a bodyweight of up to 40 kg will be half the usual recommended dose in adults and for those children and adolescents with a body weight greater than 40 kg, the dose will be the same usual recommended dose in adults.

You will need to take the whole tablets by mouth (by mouth). To facilitate administration, they can be suspended in water or orange juice, shaken, and ingested immediately.

If you think the action of this medicine is too strong or weak, tell your doctor.

Like all medicines, this Gastrointestinal Treatment medication can cause side effects, although not everyone gets them.

Very few cases of a severe allergic reaction (including severe skin erosions that can affect the skin as a protective barrier to the body) have been reported. The allergic reaction could lead to swelling of the face and neck and/or difficulty breathing or swallowing (Quincke's edema). If this happens contact your doctor or emergency department immediately.

The following common side effects affect between 1 and 10 of every 100 treated patients:

• headache
• diarrhea
• sickness
• abdominal pain
• vomiting
• acne
• flatulence (gases)

The following rare side effects affect between 1 and 10 of every 10,000 patients treated:

• inflammation of some areas of the heart (myocarditis and pericarditis) that can cause shortness of breath and chest pain or palpitations (fast or irregular heartbeat)
• inflammation of the pancreas (includes symptoms of back and/or stomach pain) and increased amylase
• dizziness
• increased skin sensitivity to sunlight and ultraviolet (photosensitivity)

The following very rare side effects affect less than 1 in 10,000 treated patients:

• eosinophilia (as part of an allergic reaction) and blood disorders such as reduced red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia), which can increase the chance of infection or bleeding.
• liver disorders (hepatitis) characterized by symptoms including jaundice (yellowing of the skin and/or eyes) and/or white stool.
• kidney disorders (symptoms include blood in the urine, a change in the color of the urine, edema (swelling due to increased fluids that can cause ankle swelling, and increased blood pressure (nephritis))
• peripheral neuropathy (a condition that affects the nerves of the hands and feet including symptoms of tickling and numbness)
• pulmonary and fibrotic allergic reactions (symptoms include cough, shortness of breath, bronchospasm, bleeding and/or excessive phlegm)
• hair loss (this is reversible)
• muscle or joint pain
• inflammation that can affect various parts of the body such as the joints, skin, kidneys, heart, etc. (symptoms include aching joints, fatigue, fever, abnormal or unexplained bleeding (for example, bleeding from the nose), bruising, purple discoloration of skin, spots under the skin (including severe skin erosions and severe burning that can affect the skin as a protective barrier for the body)
• semen with a low concentration of sperm (oligospermia) (this is reversible)
• severe diarrhea and abdominal pain due to an allergic reaction to this drug in the intestine
• allergic reactions and fever may occasionally occur

You can buy Mezavant tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy these Gastrointestinal tablets online, use Pharmacy Planet, a UK pharmacy you can trust.