Mebeverine tablets are a musculotropic antispasmodic that acts directly on the smooth muscle of the gastrointestinal tract, relieving spasms without ...

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What is Mebeverine?

Mebeverine hydrochloride tablets are musculotropic antispasmodics with direct action on the smooth muscle of the gastrointestinal tract, which relieves spasms without affecting the normal motility of the intestine. It works by interfering with the transport of calcium through the membrane of smooth muscle cells. Since this action is not mediated by the autonomic nervous system, the classic anticholinergic side effects do not occur. The Mebeverine tablet is rapidly and completely absorbed after oral administration. The drug is not excreted as such but is metabolized in the liver giving veratric acid and mebeverine alcohol, which are eliminated in the urine as such or as conjugates. The elimination is total in 24 hours.

How does it work?

Known as an excellent gastrointestinal treatment, Mebeverine is rapidly and completely absorbed after oral administration in the form of tablets. Mebeverine is not excreted as such but is completely metabolized. The first step in metabolism is hydrolysis, originating veratric acid and mebeverine alcohol. Mebeverine alcohol is an active metabolite that undergoes further metabolism, causing mebeverine demethylated carboxylic acid (ACDM) and mebeverine carboxylic acid. Finally, all metabolites are excreted in the urine. In plasma, ACDM is the major circulating metabolite. The steady-state elimination half-life of ACDM is t½ = 2.45 h after administration of the tablet. The Cmax and Tmax of the ACDM for the tablet are 1670 ng/ml and 1 h respectively. No significant accumulation occurs after the administration of multiple doses.

What are the benefits of taking it?

Mebeverine tablets belong to a group of medicines called "antispasmodics", which act on the intestine. The intestine is a long tubular muscular organ that serves for the passage and digestion of food. If the intestine spasms or contracts too much, pain is felt. This medication works by resolving spasms and pain.

The main active ingredient (Colofac) addresses the symptoms caused by irritable bowel syndrome. Colofac uses include the excellent treatment of the following symptoms:

  • stomach cramps and pain
  • bloating and flatulence
  • diarrhea, constipation, or a combination of both
  • stool made of small hard balls or beads

How do I use it and its dosage?

Always use this medicine according to a doctor's instructions or according to the instructions in the package leaflet. The general guidelines for taking Mebeverine medication are as follows:

  • Take the tablet with a little water
  • Choose a fixed time to take this medicine. This way, it will be more difficult for you to forget to take a dose

Primary irritable colon syndrome and other pathologies usually included in this group such as chronic irritable colon, spastic constipation, mucous colitis, spastic colitis:

Adults: the manufacturer's recommended doses are 405 mg/day, distributed in three administrations before meals. Often a month or more of treatment is necessary due to indications for which this drug is recommended.

Abdominal spasm secondary to organic diseases such as diverticulosis and diverticulitis: Adults:

The recommended doses are 405 mg/day, distributed in three administrations before meals.


The safety and efficacy of mebeverine in this population have not been evaluated.

Treatment of dysmenorrhea:

Adults: doses of 135 mg twice daily have been used.

Side effects & precautions

Like all medicines, this medicine can cause side effects, although not everybody gets them. Stop taking Mebeverine tablets and see a doctor immediately if you experience any of the following serious side effects, as you may need urgent medical treatment. The list below is a list of the known Mebeverine side effects, these include:

  • Difficulty breathing
  • Swelling of the face, neck, lips, tongue, or throat

Other adverse effects are:

You may experience a milder allergic (hypersensitivity) reaction to the medicine - for example

  • A rash
  • Redness
  • itchy skin
  • Dizziness
  • Drowsiness
  • Confusion
  • Nausea

Precautions when taking Mebeverine.

If you are allergic (hypersensitive) to this active ingredient or to any of the other components of the pharmaceutical specialty that have been prescribed for you. If you think you may be allergic, consult your doctor.

Allergy symptoms may include

  • Asthma crisis, with shortness of breath, breathing with audible whistles, or rapid breathing.
  • More or less sudden swelling of the face, lips, tongue, or other parts of the body. It is especially critical if it affects the vocal cords
  • Urticaria, itching, rash
  • Anaphylactic shock (loss of consciousness, paleness, sweating, etc).

You should also not take this medicine.

  • If you have an episode of paralytic ileus,
  • If you are breast-feeding your child,
  • If you have cystic fibrosis,
  • If you are under 18 years of age

Take special care with mebeverine

  • If you have liver failure,
  • If you are pregnant, planning to become pregnant, or think you may be. Do not take this medicine without your doctor's instructions
  • If you have kidney failure.

Buying Mebeverine online.

You can buy Mebeverine online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy Mebeverine tablets online, use Pharmacy Planet, a UK pharmacy you can trust.

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