The Intal inhaler is a medicinal inhaler that contains the main active ingredient, Cromolyn sodium, that acts on the surface ...

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The Intal inhaler is a medicinal inhaler that contains the main active ingredient, Cromolyn sodium, that acts on the surface of mast cells inhibiting their degranulation. This, in turn, prevents the release of histamine and the slow reaction of the substance anaphylaxis (SRS-A), both mediators of type 1 allergic reactions.

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What is the Intal inhaler?

The Intal inhaler is a medicinal inhaler that contains the main active ingredient, Cromolyn sodium, it is an active synthetic compound that, which, without possessing bronchodilator activity, has the ability to inhibit antigen-induced bronchospasm. Currently, its main use is as a prophylactic agent in the treatment of mild to moderate asthma.

How does it work?

The cromolyn in the intal nebulizer solution (the inhaler) acts on the surface of mast cells inhibiting their degranulation. This, in turn, prevents the release of histamine and the slow reaction of the substance anaphylaxis (SRS-A), both mediators of type 1 allergic reactions. cromolyn may also reduce the release of inflammatory leukotrienes. cromolyn has been postulated to produce these effects by inhibiting calcium influx, but its exact mechanism of action is unclear. The cromolyn does not interfere with the binding of IgE to mast cells or with the binding of the antigen to IgE. Because cromoglycate is not a bronchodilator, antihistamine, or vasoconstrictor, its beneficial effects in the treatment of asthma are largely prophylactic. cromolyn may reduce hyperreactivity of the bronchi, inhibition of asthmatic responses to antigenic stimulation (eg, cold air, allergens, environmental pollutants) or exercise. cromolyn has also been administered orally to treat inflammatory bowel disease.

What are the benefits of taking it?

The Intal asthma inhaler is used as a preventive treatment of bronchial asthma (extrinsic or intrinsic) in children and adults, induced by exercise, climatic changes such as humidity and cold air, chemical and other irritants, stress, etc. Avoid immediate and late responses in bronchial asthma, even in the presence of the antigen.

How do I use it and its dosage?

Treatment with the Intal inhaler is preventive, so it is important to maintain a regular dose. The patient should be informed that because multiple doses may be necessary to verify the benefit, relief may not be immediately apparent as it may take a few weeks to develop. The recommended dose is 10 mg sodium cromoglycate (two inhalations with the 5 mg aerosol) four times a day. The suggested dose regimen is two inhalations at bedtime, and two inhalations upon waking in the morning (every 12 hours). The rest of the scheme can be administered at regular intervals every 3 to 6 hours throughout the day. The dose can be increased to two inhalations 6 to 8 times a day, in the most severe cases, or during periods of high exposure to antigens. When the asthmatic condition stabilizes, it is sometimes possible to reduce the dose, although this must be carefully evaluated in each patient, to ensure adequate control of asthma. The addition of sodium cromoglycate in patients who are currently being treated with oral or inhaled steroids may allow a reduction or discontinuation of the steroid dose. For protection against exercise-induced bronchospasm or other known triggering factors, INTAL® 5 should be used 15-30 minutes before exposure to the trigger factor. It is essential to instruct the patient on how to correctly use the inhaler.

Side effects & precautions

There are a number of side effects that could potentially arise when using the Intal inhaler, now, it is to remain clear that the side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of the population that has used this medication. The following section is a list of known intal inhaler side effects, these include:

  • Coughing
  • difficulty sleeping
  • Dizziness
  • Drowsiness
  • dry or irritated throat
  • faster heartbeat (usually temporary)
  • Fatigue
  • Flushing
  • Headache
  • Irritability
  • Nausea
  • Nervousness
  • Restlessness
  • tremor (shakiness)
  • viral infections of the nose and throat (fever, sore throat, runny nose)
  • Weakness

CONTRAINDICATIONS AND PRECAUTIONS

Cromolyn can cause serious anaphylactic reactions and is contraindicated in patients with known hypersensitivity to cromolyn. Sodium cromoglycate is not a bronchodilator and is contraindicated in the treatment of acute bronchospasm or asthmatic state. The aerosol preparation of cromolyn sodium is contraindicated in patients with heart disease, such as coronary artery disease and/or cardiac arrhythmias because the aerosol contains fluorocarbon as a propellant.

Sodium cromoglycate for ophthalmic use contains benzalkonium chloride as a preservative, and wearers of soft contact lenses should be warned against wearing the lenses during treatment.

Oral cromoglycate preparations should not be administered by inhalation or injection. Oral cromoglycate preparations contain lactose.

The recommended dose of oral cromolyn sodium should be reduced in patients with liver disease or renal impairment due to the renal and biliary routes and renal routes of drug excretion.

Buying the Intal inhaler online.

You can buy the Intal inhaler online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy an Intal inhaler online, use Pharmacy Planet, a UK pharmacy you can trust.

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