Insulatard injection solution is used to reduce high blood sugar levels in patients with diabetes. mellitus (diabetes). Diabetes is a disease in which your body does not produce enough insulin to control blood sugar levels. Insulatard treatment helps prevent diabetes complications.

Insulatard begins to lower your blood sugar level about 1 hour and a half after injection and effect last for about 24 hours. Insulatard is usually administered in combination with fast-acting insulin preparations.

The hypoglycemic effect of insulin occurs when it binds to insulin receptors in muscle and fat cells, facilitating the absorption of glucose and simultaneously inhibiting hepatic glucose production. Insulatard is human insulin with a gradual onset of action and a long duration. The action starts at one and a half hours, the maximum effect occurs between 4 and 12 hours after administration, with an approximate duration of action of about 24 hours.

Insulatard is a suspension for injection whose active ingredient is human insulin. It is supplied in vials, cartridges or prefilled pens. The main benefit of Insulatard is that it is used as a treatment for diabetes. This medication can only be dispensed with a prescription.

Follow exactly the instructions for the administration of this medicine and the dose indicated by your doctor. If in doubt, ask your doctor, pharmacist, or nurse again.

Do not change insulin unless your doctor tells you to. If it changes you from a type or brand of

insulin to another, you may need to make a dose adjustment.

The Insulatard injection dose is individual and is determined according to the patient's needs. The doctor will determine if the patient needs one or more injections daily. Insulatard can be administered alone or in combination with rapid-acting insulin. In intensive insulin treatment, suspensions can be used as basal insulin (injection at night and / or in the morning) together with fast-acting insulin at meals. The monitoring of blood glucose levels is recommended for optimal glycemic control.

Insulin requirements are individual and are normally between 0.3 and 1.0 international units/kg/day.

Dose adjustment may be necessary if patients increase their physical activity, change their usual diet or during concomitant illness

How and where to inject insulin

Insulatard is given by injection under the skin (subcutaneous administration). Should never inject directly into a vein (intravenous injection) or muscle (intramuscular injection).

Insulatard FlexPen is only indicated for injection under the skin. Check with your doctor if you need to inject insulin by another method. With each injection, change the injection site within the particular area of skin you use. This can reduce the risk of developing skin bumps and depressions. The best areas for injection are as follows: the front of the waist (abdomen), the gluteal region, the front of the thigh, and the upper outside of the arm. The effect of insulin it will be faster if the injection is made in the waist (abdomen). You should measure your blood sugar in blood regularly.

How to handle Insulatard FlexPen 

Insulatard FlexPen is a disposable pre-filled pen containing isophane human insulin (NPH). You must use the pen as described in the Instructions for using Insulatard FlexPen.

Always be sure to use the correct pen before injecting your insulin.

Like all medicines, this medicine can cause side effects, although it does not all people suffer them.

Signs of a drop in blood sugar:

• cold sweat, cold, pale skin, headache,
• fast heartbeat, feeling unwell, excessive appetite, temporary visual disturbances,
• unusual drowsiness, tiredness and weakness, nervousness or trembling, anxiety, confusion,
• difficulty concentrating
• A severe drop in blood sugar level can lead to loss of consciousness.

List of other adverse effects 

Allergy symptoms:

• local allergic reactions may occur (pain, redness, hives, inflammation, bruising, swelling, and itching) at the injection site.
• Alterations at the injection site (lipodystrophy): the fatty tissue under the skin at the point of injection can be reduced (lipoatrophy) or increased (lipohypertrophy). Changing the injection point each time you inject you can reduce your risk of these skin changes.
• Diabetic retinopathy (a diabetes-related eye disease that can lead to loss of vision): If you have diabetic retinopathy and your blood sugar level improves very quickly, retinopathy can worsen. In this case, you should consult your doctor.
• Inflammation of the joints: when starting insulin treatment, fluid accumulation. It can cause inflammation of the ankles and other joints. This effect usually disappears quickly. If not, talk to your doctor.

Very rare side effects (they can affect up to 1 in 10,000 people).

• Vision problems: when you start insulin treatment, your vision may be affected, but it is usually temporary.
• Painful neuropathy (pain due to nerve damage) - if your blood sugar level improves very quickly, you may experience nerve-related pain. It is what is known as painful neuropathy acute and is usually transient.

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