Desmopressin Tablets

The active substance that makes the tablet work (the active substance) is desmopressin. Desmopressin is an antidiuretic, which reduces the amount of urine produced by the kidneys.

Desmopressin is a synthetic structural analogue of the pituitary hormone natural arginine-vasopressin. Desmopressin is distinguished from natural hormone by two chemical differences: deamination of cysteine ​​and the replacement of 8-L-arginine by 8-D-arginine. This change considerably prolongs the antidiuretic effect and casielimina the pressor effect at therapeutic doses. Desmopressin is a very powerful agent with an EC50 of 1.6 pg/ml with an antidiuretic effect. The duration of the expected effect after oral administration is 6 to 14 hours or more.

Desmopressin is used to treat:

• A chronic disease called central diabetes insipidus, which causes a lot of thirst and the continued formation of large amounts of urine. Important: Do not confuse with Diabetes mellitus (sugar diabetes)
• Enuresis in children (involuntary nocturnal urination) older than 5 years.
• Frequent need to urinate at night in adults (nocturia).

Follow the exact instructions for the administration of this medicine indicated by your doctor or pharmacist. If in doubt, consult your doctor or pharmacist again.

Treatment with Desmopressin for increased nighttime urination in adults (nocturia) should be initiated and controlled by specialists experienced in this treatment.

Divide the tablets in half or swallow them whole

Do not take Desmopressin with food as the effect of the tablets may be reduced.

During treatment with Desmopressin, you should regularly check your body weight, the level of sodium in your blood and/or blood pressure.

The recommended dose is:

Central diabetes insipidus

Adults and children: 100 micrograms (0.1 mg) three times a day. Your doctor may increase the dose depending on the response to your symptoms.

Nocturnal enuresis (involuntary urination at night)

Children older than 5 years: 200 micrograms (0.2 mg) before bed. Your doctor may increase the dose to 400 micrograms (0.4 mg) at bedtime depending on the response to bedwetting. The need to continue treatment is usually checked every three months by inserting a period without treatment for at least one week.

Frequent urge to urinate at night (nocturia)

Adults: 100 micrograms (0.1 mg) before bedtime. The dose can be increased to 200 micrograms (0.2 mg) and subsequently to a maximum of 400 micrograms (0.4 mg) at 1-week intervals. Before starting treatment, urine production should be measured. If nocturia does not improve after four weeks, consult your doctor as treatment should be stopped.

Elderly: treatment of nocturia in the elderly is not recommended. If your doctor decides to treat you, blood sodium levels should be measured before and three days after starting treatment, and if the dose is increased or at any time your doctor deems it necessary.

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Discontinue treatment and consult your doctor immediately if the following occurs

Symptoms resulting from fluid retention, such as unusual or prolonged headache, feeling or being sick, unexplained weight gain, and in severe cases, unconsciousness, seizures, allergic reactions such as rash, itching, fever, swelling of the mouth, tongue, or airways causing difficulty swallowing or breathing.

Tell your doctor or pharmacist if you notice any of the following side effects:

Very common (may affect more than 1 in 10 people): headache.

Common (may affect up to 1 in 10 people): dry mouth, abdominal pain, feeling sick, dizziness, swelling of arms and legs, weight gain, increased urinary frequency.

Very rare (may affect up to 1 in 10,000 people): emotional disorders in children, allergic reactions.

Unknown the frequency cannot be estimated from the available data: accumulation of water in the body, low sodium levels

Warnings and precautions.

The feeling of thirst is automatically inhibited with an adequate treatment of desmopressin tablets. However, there is a potential risk for fluid retention, in severe cases, water poisoning (overhydration and hyponatremia) can occur if you drink heavily during treatment with desmopressin acetate tablets. Therefore, it is recommended that this danger be warned to patients, particularly the elderly and parents of young children.

Desmopressin treatment of nocturia due to nocturnal polyuria in adults should be initiated and controlled by specialists experienced in this treatment.

For the treatment of nocturnal enuresis and nocturia, fluid intake should be limited as much as possible from 1 hour before administration to bedtime until the following morning and in any case at least 8 hours after administration of desmopressin tablets. acetate. It is therefore recommended that the consumption during this period of liquids occurs exclusively due to the sensation of thirst. Treatment should be reviewed every three months to determine if there is still a need for treatment. This can be done by sandwiching for at least a week without medication. Desmopressin acetate cannot be given for eneures in children younger than 5 years and is not recommended for nocturia in patients older than 65 years.

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