Desmopressin Melts
This medicine is used for the treatment of nocturnal enuresis and, despite being an analogue of vasopressin, it does not act on V1 receptors, responsible for the vasoconstrictor action, therefore its effect on the vessels blood is practically negligible. Desmopressin Melts dissolve in the mouth and do not need to be swallowed like other tablets. Do not take Desmopressin with food as the effect of the tablets may be reduced. During treatment with Desmopressin, you should regularly check your body weight, the level of sodium in your blood and/or blood pressure.
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| Pack | Price (£) | ||
|---|---|---|---|
| DesmoMelt | 120mcg | 30 Tablets | 74.00 |
| DesmoMelt | 120mcg | 60 Tablets | 133.00 |
| DesmoMelt | 120mcg | 90 Tablets | 195.00 |
| DesmoMelt | 240mcg | 30 Tablets | 111.00 |
| DesmoMelt | 240mcg | 60 Tablets | 198.00 |
| DesmoMelt | 240mcg | 90 Tablets | 292.00 |
| DDAVP Melt | 120mcg | 100 tablets | 160.00 |
| DDAVP Melt | 120mcg | 200 tablets | 288.00 |
| DDAVP Melt | 120mcg | 300 tablets | 421.00 |
| DDAVP Melt | 240mcg | 100 tablets | 275.00 |
| DDAVP Melt | 240mcg | 200 tablets | 495.00 |
| DDAVP Melt | 240mcg | 300 tablets | 742.00 |
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Desmopressin Melts for Bedwetting and Nocturnal Enuresis Treatment
Desmopressin melts are used to treat bedwetting and night-time urination caused by nocturnal enuresis. They are fast-dissolving tablets designed for people who produce too much urine during the night. Desmopressin melts work by reducing urine production while you sleep, allowing the bladder to stay fuller for longer and reducing night-time accidents.
Desmopressin melts dissolve on the tongue and do not need to be swallowed with water, which makes them easier to take before bedtime. Many people choose Desmopressin melts when bedwetting or frequent night-time urination is disrupting sleep, confidence, or daily life. You can order Desmopressin melts online from Pharmacy Planet following a short online consultation.
What Are Desmopressin Melts?
Desmopressin melts are fast-dissolving tablets that contain desmopressin, a synthetic version of the natural hormone vasopressin. This hormone controls how much urine the kidneys produce. Unlike natural vasopressin, desmopressin does not act on blood vessel receptors responsible for narrowing blood vessels. This means its effect on blood pressure and circulation is minimal when used at prescribed doses.
Desmopressin melts are commonly prescribed for nocturnal enuresis in children aged 5 years and over, as well as adults with night-time urination caused by excess urine production during sleep.
Common uses of Desmopressin melts include:
- Bedwetting in children aged 5 years and over.
- Nocturnal enuresis in teenagers and adults.
- Excess urine production during the night.
- Frequent waking at night to pass urine.
- Sleep disruption caused by night-time urination.
How Do Desmopressin Melts Work
Desmopressin melts are designed to control how much urine your body produces during the night. They work by copying the action of a natural hormone that manages water balance while you sleep. Desmopressin melts replace the action of antidiuretic hormone (ADH), which normally reduces urine production at night. They signal the kidneys to retain more water while you sleep, lowering the amount of urine made overnight. This allows the bladder to stay fuller for longer without overfilling, reducing bedwetting episodes and the need to wake up to pass urine. This supports uninterrupted sleep and greater confidence over time.
How to Use Desmopressin Melts?
Desmopressin melts should always be taken exactly as advised by one of our UK prescribers. The tablet is placed under the tongue, where it dissolves naturally. It should not be chewed or swallowed like a standard tablet.
Useful Tips for Best Results:
- Take Desmopressin melts just before bedtime.
- Do not take Desmopressin melts with food, as this reduces absorption.
- Avoid drinking fluids from one hour before taking the tablet until the next morning.
- Only drink if you feel thirsty during the fluid-restriction period.
- Take the tablet at the same time each night for consistent results.
Dosage Information: Adults with nocturnal enuresis are commonly prescribed between 120 micrograms and 240 micrograms at bedtime. Children and adolescents usually start on a lower dose. Dose adjustments are made gradually based on response and tolerance. If symptoms do not improve after a few weeks, treatment is reviewed. If you forget a dose, skip it and continue with your next scheduled dose. Do not take a double dose.
Who Can Use Desmopressin Melts?
Desmopressin melts may be suitable for:
- Children aged 5 years and over with bedwetting.
- Teenagers and adults with nocturnal enuresis.
- People whose night-time urination is caused by excess urine production.
- Individuals who struggle with swallowing tablets.
Desmopressin melts are not suitable for:
- Children under 5 years of age.
- Adults over 65 years for nocturia treatment.
- People with low sodium levels in the blood.
- Anyone with heart failure or conditions requiring fluid restriction.
- Anyone allergic to desmopressin or tablet ingredients.
Possible Side Effects of Desmopressin Melts
Like all medicines, Desmopressin melts can cause side effects, although not everyone experiences them.
Common Side Effects:
- Headache, nausea, stomach pain, dizziness, dry mouth, weight gain due to fluid retention
Uncommon or Rare Side Effects:
- Swelling of the hands or feet, low sodium levels in the blood, fluid retention, allergic reactions (rash or itching), seizures or confusion in severe cases of water retention
Stop taking and seek urgent medical advice if you experience severe headache, vomiting, unexplained weight gain, confusion, or swelling of the face or throat.
Important Safety Warnings and Fluid Restriction with Desmopressin Melts
Fluid control is essential during treatment with Desmopressin melts. Drinking excessive fluids can lead to water retention and dangerously low sodium levels. Limit fluid intake from one hour before taking the tablet until at least eight hours afterwards. Monitor body weight regularly. Blood sodium levels may be checked during treatment if required. Parents and carers should closely supervise fluid intake in children using Desmopressin melts.
Some medicines increase the risk of fluid retention or low sodium when taken with Desmopressin melts. Tell your prescriber about all medicines including antidepressants, anti-inflammatory medicines, epilepsy treatments, and medicines that affect water or salt balance.
Buy Desmopressin Melts Online from Pharmacy Planet
You can buy Desmopressin melts online from Pharmacy Planet following a quick and secure online consultation.
- Complete a short online consultation about symptoms and medical history.
- One of our UK prescribers reviews your information.
- If approved, Desmopressin melts are dispensed and delivered discreetly to your door.
Desmopressin melts are fast-dissolving tablets that reduce urine production overnight. They dissolve on the tongue without water, making them ideal for bedtime use. Used for bedwetting in children over 5 and adults with nocturnal enuresis.
Fast-dissolving tablets containing desmopressin (synthetic vasopressin analogue). Controls overnight urine production with minimal effect on blood pressure. Prescribed for bedwetting (children aged 5+), nocturnal enuresis in teenagers and adults, excess night-time urine production, and those who struggle swallowing tablets.
Replace the action of antidiuretic hormone (ADH), signalling the kidneys to retain more water during sleep. This lowers overnight urine production, keeps the bladder fuller for longer, and reduces bedwetting and night-time bathroom visits — supporting uninterrupted sleep and confidence.
Place under the tongue just before bedtime — do not chew or swallow like a tablet. Do not take with food. Avoid fluids from 1 hour before until next morning (drink only if thirsty). Adults: 120–240 micrograms at bedtime. Children/adolescents: lower starting dose. Skip missed doses — never double dose.
Suitable for children aged 5+ with bedwetting, teenagers/adults with nocturnal enuresis, people with excess night-time urine production, and those who struggle swallowing tablets.
Not suitable for under 5s, adults over 65 for nocturia, people with low blood sodium, heart failure, conditions requiring fluid restriction, or allergy to desmopressin.
Common: Headache, nausea, stomach pain, dizziness, dry mouth, weight gain from fluid retention
Uncommon/Rare: Hand/foot swelling, low blood sodium, fluid retention, allergic reactions, seizures/confusion in severe water retention
Seek urgent help for severe headache, vomiting, unexplained weight gain, confusion, or face/throat swelling.
Limit fluid intake from 1 hour before taking the tablet until at least 8 hours afterwards. Monitor body weight regularly. Parents/carers must supervise children's fluid intake. Tell your prescriber about all medicines including antidepressants, anti-inflammatories, epilepsy treatments, and medicines affecting water/salt balance.
You can buy Desmopressin melts online from Pharmacy Planet following a quick and secure online consultation.
- Complete a short online consultation about symptoms and medical history.
- One of our UK prescribers reviews your information.
- If approved, Desmopressin melts are dispensed and delivered discreetly to your door.
Desmopressin melts usually start working on the first night you take them. Some people notice fewer wet nights straight away, while others see steady improvement over several days.
Desmopressin melts dissolve on the tongue and do not need water, which many people find easier before bedtime. They also avoid swallowing tablets, making them suitable for children and those who struggle with tablets.
Desmopressin melts are suitable for children aged 5 years and over when prescribed. Fluid restriction at night is very important to keep treatment safe, and parents or carers should supervise this closely.
Drinking too much fluid after taking Desmopressin melts increases the risk of water retention and low sodium levels. You should avoid drinking from one hour before the dose until the next morning, unless you feel thirsty.
Yes, Desmopressin melts are prescribed for adults with nocturnal enuresis or night-time urination caused by excess urine production. They are not recommended for adults over 65 years for this purpose.
Desmopressin melts are taken nightly while treatment is ongoing. The need for continued treatment is usually reviewed every few months to see if it is still required.
Yes, bedwetting can return after stopping Desmopressin melts if your body is still producing too much urine at night. If this happens, an online consultation with one of our UK prescribers can help you decide whether restarting treatment is appropriate.

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Authored on : April 28 2026
HARMINDER ‘HARMY’ KAUR
BSc(hons) Pharmacy
GPhC Number: 2061107

Reviewed on : April 28 2026
GURDEV SEHMI
BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead
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