People also ask
What is Abasagler?
Abasagler is an injectable solution containing insulin glargine. Insulin glargine is a modified insulin, very similar to human insulin.
How does it work?
Insulin glargine is an analogue of human insulin designed to have low solubility at neutral pH. It is completely soluble at the acidic pH of the Abasaglar solution for injection (pH 4). After injection into the subcutaneous tissue, the acidic solution is neutralized, leading to the formation of micro precipitates from which small amounts of insulin glargine are continuously released, providing a smooth and predictable concentration/time profile without peak, with a long duration of action.
Insulin glargine is metabolized into 2 active metabolites M1 and M2.
Binding to the insulin receptor
In vitro studies indicate that the affinity of insulin glargine and its M1 and M2 metabolites for the human insulin receptor is similar to that of human insulin.
Binding to the IGF-1 receptor: The affinity of insulin glargine for the human IGF-1 receptor is approximately 5 to 8 times greater than the affinity for this receptor for human insulin (but approximately 70 to 80 times less than the affinity of IGF-1 for the IGF-1 receptor), while M1 and M2 bind to the IGF-1 receptor with slightly lower affinity compared to human insulin.
The total therapeutic concentration of insulin (insulin glargine and its metabolites) found in type 1 diabetic patients was markedly lower than that which would be necessary for a semi-maximum IGF-1 receptor occupation and consequently the activation of the mitogenic-proliferative pathway initiated by the IGF-1 receptor. Physiological concentrations of endogenous IGF-1 can activate the mitogenic-proliferative pathway; however, the therapeutic concentrations found in insulin therapy, including Abasaglar therapy, are considerably lower than the pharmacological concentrations necessary to activate the IGF-1 pathway.
What are the benefits of taking it?
Abasagler is used in the treatment of diabetes mellitus in adult patients, adolescents, and children from 2 years of age. Diabetes mellitus is a disease in which your body does not make enough insulin to control the level of sugar in your blood. Insulin glargine has a long and constant action of reducing blood sugar.
How do I use it and its dosage?
Always use this medicine exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again.
Dose
Depending on your lifestyle and the results of your blood sugar (glucose) checks and your previous insulin treatment, your doctor:
- determine the dose of Abasaglar you need each day and at what time,
- it will tell you when to check your blood sugar level, and if you need to have a urine test,
- It will tell you when you may need to inject a higher or lower dose of Abasaglar.
Abasaglar is a long-acting insulin. Your doctor may direct you to use it in combination with short-acting insulin or with tablets to treat elevated blood sugar levels.
Many factors can influence your blood sugar level. You should be aware of these factors as you will be able to react correctly to changes in your blood sugar level and to prevent it from rising or falling too low.
Use in children and adolescents
Abasaglar can be used in adolescents and children 2 years and older. There is no experience with the use of Abasaglar in children under 2 years of age.
Administration frequency
You need an injection of Abasaglar every day, always at the same time.
Administration form
Aabasaglar is injected under the skin. DO NOT inject Abasaglar into a vein, as this will change its action and may cause hypoglycaemia.
Your doctor will show you which skin area you should inject Abasaglar into. With each injection, you need to change the puncture site within the particular area of skin you are using.
Side effects & precautions
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Hypoglycemia (low blood sugar) can be very serious. If your blood sugar level drops too low you may lose consciousness. Severe hypoglycemia can damage the brain and can be life-threatening. If you have symptoms of low blood sugar, take immediate action to raise your blood sugar.
If you have the following symptoms, contact your doctor immediately: large-scale skin reactions (rash and itching all over the body), severe swelling of the skin or mucous membranes (angioedema), difficulty breathing, decreased blood pressure with fast heartbeat and sweating. These could be the symptoms of serious allergic reactions to insulins and can be life-threatening.
Very common side effects (may affect more than 1 in 10 people)
Rare side effects (may affect up to 1 in 1,000 people)
- Serious allergic reactions to insulins
Related symptoms may include large-scale skin reactions (skin rash and itching all over the body), severe swelling of the skin or mucous membranes (angioedema), shortness of breath, decreased blood pressure with a rapid heartbeat, and sweating. . These could be the symptoms of severe allergic reactions to insulins and can be life-threatening.
Eye reactions
A significant change (improvement or worsening) in your blood sugar control can temporarily alter your vision. If you have proliferative retinopathy (a diabetes-related eye disease), severe hypoglycemic attacks can cause temporary loss of vision.
General disorders
In rare cases, insulin treatment can also cause temporary water retention in the body, with swelling of the calves and ankles.
Very rare side effects (may affect up to 1 in 10,000 people)
In very rare cases, it can cause dysgeusia (taste disorders) and myalgia (muscle pain).
Other side effects of unknown frequency (frequency cannot be estimated from the available data)
Insulin treatment can cause the body to make antibodies to insulin (substances that act against insulin). Rarely, this may require a change in your insulin dose.
Buying Abasagler online.
You can buy Abasagler Insulin Injection online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy Diabetes Insulin online, use Pharmacy Planet, a UK pharmacy you can trust.
